Fulcrum Therapeutics announced the appointment of Bryan E. Stuart as chief operating officer. Stuart brings more than 20 years of leadership, strategic and operational experience to Fulcrum. He most recently served as president and CEO of Yarra Theraputics. Previously he was president, then CEO of Kastle Therapeutics. He also served as chief business officer of Civitas Therapeutics. Stuart previously led business development and corporate strategy for both EKR Therapeutics and Ovation Pharmaceuticals. Stuart began his career as a healthcare investment banker at William Blair & Company.