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FORM 424B5

FIFTH THIRD BANCORP - FITB

Filed: January 24, 2019 (period: )

Prospectus filed under Rule 424(b)(5)

The information contained herein may not be copied, adapted or distributed and is not warranted to be accurate, complete or timely. The user assumes all risks for any damages or losses arising from any use of this information, except to the extent such damages or losses cannot be limited or excluded by applicable law. Past financial performance is no guarantee of future results.

Table of Contents

Filed Pursuant to Rule 424(b)(5)

Registration No. 333-210429

CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities to be Registered

Amount to be Registered

Proposed

Maximum Offering Price

Per Unit

Proposed Maximum Aggregate Offering Price

Amount of Registration Fee(1)

3.650% Senior Notes due 2024

$1,500,000,000

99.814%

$1,497,210,000

$181,461.86

(1) Calculated in accordance with Rule 457(r) of the Securities Act of 1933, as amended.

Prospectus supplement

(To prospectus dated March 28, 2016)

$1,500,000,000 3.650% Senior Notes due 2024

Interest payable January 25 and July 25

Issue price: 99.814%

Fifth Third Bancorp is offering $1,500,000,000 aggregate principal amount of 3.650% Senior Notes due 2024 (the "notes").

We will pay interest on the notes semi-annually in arrears on January 25 and July 25 of each year, beginning July 25, 2019.

The notes will mature on January 25, 2024. The notes will be unsecured senior obligations of Fifth Third Bancorp. The notes are not subject to repayment at the option of the holders at any time prior to maturity. We may redeem the notes, in whole or in part, on or after the date that is 30 days prior to the maturity date at a redemption price equal to 100% of the principal amount of the notes to be redeemed plus accrued and unpaid interest to, but excluding, the redemption date. There will be no sinking fund for the notes. The notes will be issued only in minimum denominations of $2,000 or any integral multiples of $1,000 in excess thereof.

See "Risk factors" beginning on page S-5 of this prospectus supplement and in the documents incorporated by reference in this prospectus supplement for a discussion of certain risks that you should consider in connection with an investment in the notes.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the notes or determined that this prospectus supplement or the accompanying prospectus is accurate or complete. Any representation to the contrary is a criminal offense.

Underwriting

Price to public

Discount

Proceeds to us

Per Note

99.814%

0.350%

99.464%

Total

$1,497,210,000

$ 5,250,000

$1,491,960,000

The price to the public set forth above does not include accrued interest, if any. Interest on the notes will accrue from January 25, 2019.

The notes are not savings accounts, deposits or other obligations of any of our bank or non-bank subsidiaries and are not insured or guaranteed by the Federal Deposit Insurance Corporation or any other governmental agency.

The notes will not be listed on any securities exchange or interdealer market quotation system. Currently, there is no public market for the notes.

We expect that the notes will be ready for delivery through the book-entry facilities of The Depository Trust Company, Clearstream Banking, Société Anonyme or Euroclear Bank S.A./N.V., as operator of the Euroclear System, as applicable, against payment in New York, New York on or about January 25, 2019.

Joint Book-Running Managers

Morgan Stanley

Fifth Third Securities

Goldman Sachs & Co. LLC

RBC Capital Markets

Co-Managers

Academy Securities

R. Seelaus & Co., LLC

The date of this prospectus supplement is January 23, 2019.

Table of Contents

Prospectus supplement

Page

About this prospectus supplement

S-ii

Where you can find more information

S-iii

Forward-looking statements

S-iv

Summary

S-1

Risk factors

S-5

Use of proceeds

S-7

Regulatory considerations

S-8

Description of the notes

S-11

Book-entry, delivery and form

S-18

Certain U.S. federal income tax consequences to non-U.S. holders of notes

S-21

ERISA Considerations

S-24

Underwriting (conflicts of interest)

S-26

Validity of the notes

S-31

Experts

S-32

Prospectus

Page

About this prospectus

2

Where you can find more information

2

Use of proceeds

3

Plan of distribution

3

Validity of securities

5

Experts

5

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Table of Contents

S-i

About this prospectus supplement

This document consists of two parts. The first part is the prospectus supplement, which describes the specific terms of this offering and certain other matters and also adds to and updates information contained in the accompanying prospectus. The second part, the accompanying prospectus, gives more general information about securities we may offer from time to time, some of which may not apply to this offering. You should read both this prospectus supplement and the accompanying prospectus, together with additional information described under the heading "Where you can find more information" in this prospectus supplement.

Unless otherwise mentioned or unless the context requires otherwise, all references in this prospectus supplement to "Fifth Third," "the Company," "we," "us," "our" or similar references mean Fifth Third Bancorp and its subsidiaries.

If the information set forth in this prospectus supplement differs in any way from the information set forth in the accompanying prospectus, you should rely on the information set forth in this prospectus supplement.

You should not assume that the information appearing in this prospectus supplement, the accompanying prospectus or any document incorporated by reference is accurate as of any date other than the date of the applicable document. Our business, financial condition, results of operations and prospects may have changed since that date.

We have not, and the underwriters have not, authorized anyone to provide any information other than that contained or incorporated by reference in this prospectus supplement or in any free writing prospectus prepared by or on behalf of us or to which we have referred you. We and the underwriters take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you.

This prospectus supplement may be used only for the purpose for which it has been prepared. We are not, and the underwriters are not, making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. Neither this prospectus supplement nor the accompanying prospectus constitutes an offer of, or an invitation on our behalf or on behalf of the underwriters to subscribe for and purchase, any securities, and may not be used for or in connection with an offer or solicitation by anyone, in any jurisdiction in which such an offer or solicitation is not authorized or to any person to whom it is unlawful to make such an offer or solicitation.

PRIIPs Regulation / Prospectus Directive / Prohibition of Sales to EEA Retail Investors

The notes are not intended to be offered, sold or otherwise made available to and should not be offered, sold or otherwise made available to any retail investor in the EEA. For these purposes, a retail investor means a person who is one (or more) of: (i) a retail client as defined in point (11) of Article 4(1) of MiFID II; or (ii) a customer within the meaning of Directive 2002/92/EC (as amended, the "Insurance Mediation Directive"), where that customer would not qualify as a professional client as defined in point (10 ) of Article 4(1) of MIFID II; or (iii) not a qualified investor as defined in Directive 2003/71/EC (as amended, the "Prospectus Directive").

Consequently no key information document required by Regulation (EU) No 1286/2014 (as amended, the "PRIIPs Regulation") for offering or selling the notes or otherwise making them available to retail investors in the EEA has been prepared and therefore offering or selling the notes or otherwise making them available to any retail investor in the EEA may be unlawful under the PRIIPs Regulation.

This prospectus supplement is not a prospectus for the purposes of the Prospectus Directive as implemented in member states of the EEA.

S-ii

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Fifth Third Bancorp published this content on 24 January 2019 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 24 January 2019 23:13:05 UTC