The scale-up and GMP batch production is to support the preparation towards the anticipated first in man proof of concept clinical trials
Rehovot,
Biose Industrie is a drug-GMP certified manufacturer of bacteria-based APIs and clinical and commercial products. Biomica engaged with Biose for the scale-up development and GMP production of a clinical batch of its drug candidates.
As previously announced, BMC121 & BMC127 were recently evaluated in pre-clinical studies in a mouse cancer model under Biomica's immuno-oncology program, aiming to improve the efficacy of immune checkpoint inhibitors therapy. The results of these trials validated the Company's computational predictions by demonstrating preliminary positive effects when administered in combination with checkpoint inhibitor therapy (anti-PD1), compared to using checkpoint inhibitor therapy alone. This effect was manifested in improved anti-tumor immune response through multiple bacterial-induced mechanisms of action.
***
Dr. Adrien Nivoliez, Biose industrie CEO, stated: "Biose Industrie is proud to collaborate with Biomica in the development of this novel LBP within the exciting field of Immuno-Oncology. This is another example of Biose Industrie's ability to support and partner for both Drug Product and Drug Substance within the world of
***
About BMC121 & BMC127
Developed as Live Bacterial Products (LBPs), BMC121 & BMC127 are rationally-designed LBP consortia comprised of unique bacterial strains that harbor specific functional capabilities with the potential to enhance immunological therapeutic responses and facilitate anti-tumor immune activity though multiple biological processes.
Rationally-designed consortia are multi-strain products designed to restore diversity and specific functionality to a host's microbial community with individually selected, cultured bacteria.
About Biomica:
Biomica is an emerging biopharmaceutical company developing innovative microbiome-based therapeutics utilizing a dedicated Computational Predictive Biology platform (CPB), licensed from
Biomica is a subsidiary of
About
Forward Looking Statements
This press release contains "forward-looking statements" relating to future events. These statements may be identified by words such as "may", "could", "expects", "intends", "anticipates", "plans", "believes", "scheduled", "estimates" or words of similar meaning. Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance or achievements of
Contact:
Investor Relation and Public Relations Manager
E: IR@evogene.com
T: +972-8-931-1940
US Investor Relations:
E: jgreen@edisongroup.com
T: +1 646-653-7030
E: lyonker@edisongroup.com
T: +1 646-653-7035
.
(C) 2020 M2 COMMUNICATIONS, source