Cardinal Health : 2023 Cardinal Health Investor Day

Moving healthcare forward

Cardinal Health Investor Day

June 8, 2023

© 2023 Cardinal Health. All Rights Reserved.

Welcome and overview

Kevin Moran, VP, Investor Relations

2 © 2023 Cardinal Health. All Rights Reserved.

• Cardinal Health Investor Day | Forward-lookingstatements

Cautions Concerning Forward-Looking Statements

This presentation contains forward-looking statements addressing expectations, prospects, estimates and other matters that are dependent upon future events or developments. These statements may be identified by words such as "expect," "anticipate," "intend," "plan," "believe," "will," "should," "could," "would," "project," "continue," "likely," and similar expressions, and include statements reflecting future results or guidance, statements of outlook and various accruals and estimates. These matters are subject to risks and uncertainties that could cause actual results to differ materially from those projected, anticipated or implied. These risks and uncertainties include risks arising from ongoing inflationary pressures and supply chain constraints, including the risk that our plans to mitigate such effects may not be as successful as we anticipate; the possibility that our Medical unit goodwill could be further impaired due to additional changes to our long-term financial plan, increases in global interest rates or unfavorable changes in the U.S. statutory tax rate; risks associated with our strategic updates, including the risk that certain initiatives may not be successful, may create unintended consequences, and the risk that we may not realize expected benefits; competitive pressures in Cardinal Health's various lines of business; the performance of our generics program, including the amount or rate of generic deflation and our ability to offset generic deflation and maintain other financial and strategic benefits through our generic sourcing venture or other components of our generics programs; ongoing risks associated with the distribution of opioids, including the financial impact associated with the settlements with governmental authorities and the risk that challenges to our plans to take tax deductions for opioid-related losses could adversely impact our financial results; risks arising from the Department of Justice investigation which we believe concerns our anti-diversion program and risks associated with the injunctive relief requirements under the national settlement, including the risk that we may incur higher costs or operational challenges in the implementation and maintenance of the required changes; risks associated with the manufacture and sourcing of certain products, including risks related to our ability and the ability of third-party manufacturers to import or export certain products or component parts and to comply with applicable regulations; our ability to manage uncertainties associated with the pricing of branded pharmaceuticals; and risks associated with our cost savings initiatives or other business process initiatives, such as the Medical Improvement Plan, including the possibility that they could fail to achieve the intended results. Cardinal Health is subject to additional risks and uncertainties described in Cardinal Health's Form 10-K, Form 10-Q and Form 8-K reports and exhibits to those reports. This presentation reflects management's views as of June 8, 2023. Except to the extent required by applicable law, Cardinal Health undertakes no obligation to update or revise any forward-looking statement. Forward-looking statements are aspirational and not guarantees or promises that goals, targets or projections will be met, and no assurance can be given that any commitment, expectation, initiative or plan in this report can or will be achieved or completed. Cardinal Health provides definitions and reconciliations of non-GAAP financial measures and their most directly comparable GAAP financial measures in the Appendix to this presentation and at ir.cardinalhealth.com.

3 © 2023 Cardinal Health. All Rights Reserved.

• Cardinal Health Investor Day | Moving healthcare forward

Overview of the day

	9:00am	Welcome and overview | Kevin Moran, VP, Investor Relations
	9:05am	Our focus | Jason Hollar, Chief Executive Officer
	9:30am	Pharmaceutical Segment: Growth and resiliency | Debbie Weitzman, Pharmaceutical Segment CEO
		Craig Cowman, EVP, Strategic Sourcing & Manufacturer Services
	10:05am	Break
	10:20am	Steve Mason, Medical Segment CEO
	Medical Improvement Plan | Ben Brinker, President, Global Products & Supply Chain
	10:45am	Value creation | Aaron Alt, Chief Financial Officer
	11:10am	Q&A | Jason Hollar, Aaron Alt, Debbie Weitzman, Steve Mason, Craig Cowman, Ben Brinker
	11:55am	Closing | Jason Hollar

*All times are Eastern Standard Time (EST)

4 © 2023 Cardinal Health. All Rights Reserved.

Our focus

Jason Hollar

Chief Executive Officer

© 2023 Cardinal Health. All Rights Reserved.