Highlights and Updates:
- MSBS technology has shown the sensitivity in the low picogram range, for THC in breath allowing for detection of THC from smoking and edibles up to 4 hours after consumption.
- Cannabix’s MSBS method for detection of THC in breath has striking differences with conventional, legacy methods [1].
Cannabix has initiated discussions with industry leading forensic laboratory organizations on how to best integrate its novel MSBS hardware into current forensic testing and analysis methods.- Scientists at
Cannabix are experimenting with a ‘quantification marker’ (using deuterated ∆9-THC as an internal standard) added to its breath sample cartridge for confirmation and potential quantification of THC in breath. Cannabix has recently delivered its BCU to theFriedel Clinic inMontana for testing with subjects.
THC detection after edibles consumption
Cannabis and its extracted active ingredients are commonly mixed into various types of food, including brownies, cookies, and candy. After eating an edible containing marijuana, THC is absorbed into the bloodstream through the digestive tract and undergoes a first metabolic pass in the liver before entering general circulation. Metabolism through the liver further reduces the amount of analyte that makes its way through to the breath relative to smoking. Figure 1 presents the “THC in breath from edibles” up to 165 minutes after consumption (averaging breath results from 5 subjects) using the Cannabix BCU collection and MSBS analysis method (data at T=0min is collected before consumption). The edibles (gummies and capsules) consumed by various subjects contained a low of 10mg and a high of up to 600mg of infused THC.
MSBS compared to legacy LCMS methods
The MSBS is a novel method for efficient collection of analytes of low volatility from human breath utilizing liquid secondary adsorption. The concept has successfully demonstrated efficient capturing and releasing of THC. This novel method uses the breath aerosol as a carrier of solid and viscous liquid particle analytes as well as a secondary adsorbent to prevent sample loss from droplet surface contact and deposition.
MSBS Technology and BCU
The Company’s handheld Breath Collection Unit (“BCU”, Figure. 2) and mass spectrometer coupled laboratory “MS Breath Sampler” (Figure. 3) are being used together to provide a new method for drug detection that complements gold-standard mass spectrometry (MS) and significantly simplifies laboratory analysis methods, reduces sample turnaround times (thus minimizing operating costs), while maintaining sensitive, precise results.
References
- Jeerage KM, Beuning CN, Friss AJ, Bidwell LC, Lovestead TM. THC in breath aerosols collected with an impaction filter device before and after legal-market product inhalation-a pilot study. J Breath Res. 2023 May 22;17(3):037103. doi: 10.1088/1752-7163/acd410.
About
We seek Safe Harbor.
On behalf of the Board of Directors
“Rav Mlait”
CEO
For further information, contact the Company at info@cannabixtechnologies.com
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Cautionary Statement Regarding Forward-Looking Statements
This press release contains forward-looking information that involves various risks and uncertainties regarding future events. Such forward-looking information can include without limitation statements based on current expectations involving a number of risks and uncertainties and are not guarantees of future performance of the Company, such as final development of a commercial or prototype product(s), successful trial or pilot of company technologies, no assurance that commercial sales of any kind actually materialize; no assurance the Company will have sufficient funds to complete product development. There are numerous risks and uncertainties that could cause actual results and the Company’s plans and objectives to differ materially from those expressed in the forward-looking information, including: (i) adverse market conditions; (ii) risks regarding protection of proprietary technology; (iii) the ability of the Company to complete financings; (iv) the ability of the Company to develop and market its future product; and (v) risks regarding government regulation, managing and maintaining growth, the effect of adverse publicity, litigation, competition and other factors which may be identified from time to time in the Company's public announcements and filings. There is no assurance that its development of marijuana breathalyzer technology will provide any benefit to the Company, and no assurance that any proposed new products will be built, will be successful in beta testing or clinical trials. There is no assurance that existing “patent pending” technologies licensed by the Company will receive patent status by regulatory authorities. The Company is not currently selling commercial breathalyzers. Actual results and future events could differ materially from those anticipated in such information. These and all subsequent written and oral forward-looking information are based on estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. Except as required by law, the Company does not intend to update these forward-looking statements
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Cannabix Technologies Inc.
Cannabix Technologies MSBS Technology Figure 2 and 3
Cannabix Technologies Inc.
Cannabix Technologies THC Detected in Breath from Edibles
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