Vividion is a biopharmaceutical company, and a wholly owned and independently operated subsidiary of
'The initiation and dosing of the first clinical trial with our STAT3 inhibitor program marks a major inflection point for Vividion as this is the second program from our platform that we have advanced into the clinic in just a few months. We are proud of the progress we have made in a relatively short amount of time with a pipeline consisting of previously undruggable protein targets for prominent oncology and immunology diseases,' said
'We are leveraging Vividion's innovative chemoproteomics drug discovery technology to develop new therapies that are addressing high profile cancer targets with the potential to stop or reverse the progression of disease,' said
VVD-130850 is an oral small molecule inhibitor of STAT3 binding to a novel allosteric pocket leading to direct inhibition of DNA binding and expression of STAT3 target genes in cancer cells. The Phase I clinical trial will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of VVD-130850 in patients with advanced solid and hematologic tumors as a single-agent and in combination with immune checkpoint inhibition.
'We are excited to announce the initiation and dosing of this highly selective STAT3 inhibitor,' said
The company is advancing multiple novel drug discovery programs toward the clinic and has more than a dozen similar pipeline opportunities emerging in early discovery in the fields of oncology and immunology. Following the company's acquisition by Bayer in
About STAT3
Signal transducer and activator of transcription 3 (STAT3) is a key regulatory protein, which become hyperactivated in certain human cancers where it can promote tumor progression, metastasis, and decreased immune responses. Owing to its role in tumor formation, metastasis as well as drug resistance and immunosuppression, the STAT3 pathway is recognized as a promising therapeutic target in a wide range of cancers.
About Vividion
About Bayer
Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2022, the Group employed around 101,000 people and had sales of
Contact:
Tel: +1 858.630.8246
Email: lauries@vividion.com
Tel: +49 172 8693420
Email: lisa.hennig@bayer.com
Forward-Looking Statements
This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conformthem to future events or developments.
(C) 2024 Electronic News Publishing, source