Barclays : Publication of Prospectus Supplement

Supplement Number 4 dated 27 October 2022 to the Base Prospectus dated 7 March 2022

BARCLAYS PLC

(incorporated with limited liability in England and Wales)

as Issuer

£60,000,000,000

Debt Issuance Programme

This base prospectus supplement (the "Supplement") is supplemental to, forms part of and must be read in conjunction with, the base prospectus dated 7 March 2022, as supplemented by Supplement Number 1 dated 24 May 2022, Supplement Number 2 dated 29 July 2022 and Supplement Number 3 dated 3 October 2022 (together, the "Base Prospectus") prepared by Barclays PLC (the "Issuer") with respect to its £60,000,000,000 Debt Issuance Programme (the "Programme"). This Supplement constitutes a supplementary prospectus in respect of the Base Prospectus for the Issuer for the purposes of Article 23 of Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14 June 2017 as it forms part of domestic law of the United Kingdom by virtue of the European Union (Withdrawal) Act 2018, as amended (the "UK Prospectus Regulation").

Terms defined in the Base Prospectus shall, unless the context otherwise requires, have the same meaning when used in this Supplement.

This Supplement has been approved by the United Kingdom Financial Conduct Authority (the "FCA"), as competent authority under the UK Prospectus Regulation, as a base prospectus supplement issued in compliance with the UK Prospectus Regulation. The FCA only approves this Supplement as meeting the standards of completeness, comprehensibility and consistency imposed by the UK Prospectus Regulation. Such approval should not be considered as an endorsement of the Issuer that is the subject of this Supplement. With effect from the date of this Supplement the information appearing in, or incorporated by reference into, the Base Prospectus shall be supplemented in the manner described below.

The purpose of this Supplement is to:

1. supplement the section entitled "Information Incorporated by Reference" commencing on page 25 of the Base Prospectus and incorporate by reference into the Base Prospectus the unaudited Interim Results Announcement of the Issuer, as filed with the SEC on Form 6-K (including exhibits thereto) on 26 October 2022 in respect of the nine months ended 30 September 2022 (the "Q3 Results Announcement"). The Q3 Results Announcement has been filed with the FCA and shall be deemed to be incorporated in, and form part of, the Base Prospectus as supplemented by this Supplement. The Q3 Results Announcement may be inspected during normal business hours at Barclays Treasury, 1 Churchill Place, London, E14 5HP, United Kingdom and at the specified office of the Principal Paying Agent, at 160 Queen Victoria Street, London, EC4V 4LA, United Kingdom during the life of the Notes issued pursuant to the Base Prospectus. It has also been filed with the SEC and is available in electronic form on the SEC's website at https://www.sec.gov/cgi-bin/browse-edgar?company=barclays+plc&owner=exclude&action=getcompany;
2. • 1-

1. replace the section entitled "Forward-LookingStatements" commencing on page vii of the Base Prospectus with the following updated information:
   "This Base Prospectus and certain documents incorporated by reference herein contain certain forward looking statements within the meaning of Section 21E of the U.S. Securities Exchange Act of 1934, as amended, and Section 27A of the U.S. Securities Act of 1933, as amended, with respect to the Issuer and its consolidated subsidiaries (the "Group" or "Barclays"). The Issuer cautions readers that no forward-looking statement is a guarantee of future performance and that actual results or other financial condition or performance measures could differ materially from those contained in the forward-looking statements. These forward-looking statements can be identified by the fact that they do not relate only to historical or current facts. Forward-looking statements sometimes use words such as "may", "will", "seek"', "continue", "aim", "anticipate",
   "target", "projected", "expect", "estimate", "intend", "plan", "goal", "believe", "achieve" or other words of similar meaning. Examples of forward-looking statements include, among others, statements or guidance regarding or relating to the Group's future financial position, income levels, assets and liabilities, impairment charges, provisions, capital, leverage and other regulatory ratios, capital distributions (including dividend pay-out ratios and expected payment strategies), projected levels of growth in banking and financial markets, projected expenditures, costs or savings, any commitments and targets (including, without limitation, environmental, social and governance ("ESG") commitments and targets), business strategy plans and objectives for future operations, group structure, International Financial Reporting Standards ("IFRS") impacts and other statements that are not historical or current facts. By their nature, forward-looking statements involve risk and uncertainty because they relate to future events and circumstances.
   Forward-looking statements speak only as at the date on which they are made. Forward-looking statements may be affected by a number of factors, including, without limitation: changes in legislation, regulation and the interpretation thereof, the development of IFRS and other accounting standards, including evolving practices with regard to the interpretation and application of accounting standards, emerging and developing ESG reporting standards, the outcome of current and future legal proceedings and regulatory investigations and any related impact on provisions, the policies and actions of governmental and regulatory authorities, the Group's ability along with governments and other stakeholders to measure, manage and mitigate the impacts of climate change effectively, environmental, social and geopolitical risks and incidents or similar events beyond the Group's control, and the impact of competition. In addition, factors including (but not limited to) the following may have an effect: capital, leverage and other regulatory rules applicable to past, current and future periods; UK, the United States ("U.S."), Eurozone and global macroeconomic and business conditions, including inflation; volatility in credit and capital markets; market related risks such as changes in interest rates and foreign exchange rates; changes in valuation of credit market exposures; changes in valuation of issued securities; changes in credit ratings of any entity within the Group or any securities issued by such entities; changes in counterparty risk; changes in consumer behaviour; the direct and indirect consequences of the Russia-Ukraine War on European and global macroeconomic conditions, political stability and financial markets; direct and indirect impacts of the coronavirus (COVID-19) pandemic; instability as a result of the UK's exit from the European Union (the "EU"), the effects of the EU-UK Trade and Cooperation Agreement and the disruption that may subsequently result in the UK and globally; the risk of cyber-attacks, information or security breaches or technology failures on the Group's reputation, business or operations; the Group's ability to access funding; and the success of acquisitions, disposals and other strategic transactions. A number of these influences and factors are beyond the Group's control. As a result, the Group's actual financial position, future results, capital distributions, capital, leverage or other regulatory ratios or other financial and non-financial metrics or performance measures or ability to meet commitments and targets may differ materially from the statements or guidance set forth in the Group's forward-looking statements. Additional risks and factors which may impact the Group's future financial condition and performance are identified in the Issuer's filings with the SEC (including, without limitation, in the 2021 Annual Report and the Interim Results Announcement (each as defined in the "Information Incorporated by Reference" section below)) which are available on the SEC's website at www.sec.gov.
   Subject to Barclays' obligations under the applicable laws and regulations of any relevant jurisdiction (including, without limitation, the UK and the U.S.), in relation to disclosure and

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ongoing information, we undertake no obligation to update publicly or revise any forward-looking statements, whether as a result of new information, future events or otherwise.";

1. update the address of the Principal Paying Agent where it occurs in the following places:
2. • paragraph 1 of the Terms and Conditions on page 37 of the Base Prospectus (whereby the reference to "7 March 2022" shall also be updated to read the date of this Supplement);
   • sub-section6 entitled "Documents on Display" of the section entitled "General Information" on page 167 of the Base Prospectus; and
   • the list of addresses on page 169 of the Base Prospectus, under "PRINCIPAL PAYING AGENT, FOREIGN EXCHANGE AGENT, AGENT BANK AND TRUSTEE",

from to "One/1 Canada Square, London, E14 5AL, United Kingdom" to "160 Queen Victoria Street, London, EC4V 4LA, United Kingdom";

1. replace the sub-section entitled "Legal Proceedings" under the section entitled "The Issuer and the Group" on page 134 of the Base Prospectus with the following:
2. 1. 
      "Legal Proceedings
      For a description of the governmental, legal or arbitration proceedings that the Issuer and the Group face, see (i) Note 21 (Legal, competition and regulatory matters) to the condensed consolidated interim financial statements of the Issuer on pages 91 to 98 of the Interim Results Announcement,
   2. the first four bullet points of the section entitled 'Group Finance Director's Review - Other matters' on page 11 of the Q3 Results Announcement and (iii) the section entitled 'Supplementary Information - Update on related litigation and conduct matters' on page 53 of the Q3 Results Announcement";
3. amend the sub-section entitled "Directors" under the section entitled "The Issuer and the Group" commencing on page 134 of the Base Prospectus by replacing it with the following updated information:

	"Name	Function(s) within the Issuer	Principal outside activities
	Nigel Higgins	Group Chairman		Chairman		and	Non-Executive
				Director, BBPLC; Chairman, Sadler's
				Wells; Non-Executive Director, Tetra
				Laval	Group;	Non-Executive
				Director, Garsington Opera Limited;
				Member, Trilateral Commission
	C.S Venkatakrishnan	Group Chief Executive	and	Chief Executive	and	Executive
		Executive Director		Director,	BBPLC;	Board	Member,
				Institute	of	International	Finance;
				Advisory Member of the Board,
				Massachusetts		Institute	of
				Technology Golub Centre for Finance
				and Policy
	Anna Cross*	Group Finance Director	and	Group	Finance	Director	and
		Executive Director		Executive	Director, Barclays	PLC;
				Director, Cross Consulting Limited
	Michael Ashley	Non-Executive Director		Non-Executive Director,	BBPLC;
				Non-Executive Director, Barclays
				Capital Securities Limited; Member,
				Cabinet	Office	Board;	Member,
				ICAEW Ethics Standards Committee;
				Member,	UK	Endorsement	Board;
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		Treasurer,	The	Scout	Association;
		Chairman, Hillywood Investments
Robert Berry*	Non-Executive Director	Non-Executive	Director,		BBPLC;
		Non-Executive Director, Barclays
		Capital	Securities	Limited;	Board
		President,	Alina	Lodge;	Finance
		Committee	Member,	Peer	Health
		Exchange; Member of the Board of
		Trustees, Wardlaw + Hartidge School
Tim Breedon	Non-Executive Director	Chairman,	Barclays Bank		Ireland
		PLC; Chairman, Apax Global Alpha
		Limited; Non-Executive Director,
		Quilter PLC
Mohamed A. El-Erian	Non-Executive Director	Non-Executive	Director,		BBPLC;
		Lead Independent	Director,	Under
		Armour		Inc.;	Chief	Economic
		Advisor,		Allianz	SE;	Chairman,
		Gramercy Funds Management; Senior
		Advisor,		Investcorp	Bank	BSC;
		President,	Queens'			College,
		Cambridge University
Dawn Fitzpatrick	Non-Executive Director	Non-Executive	Director,		BBPLC;
		Non-Executive Director, Barclays
		Capital	Securities	Limited;	Chief
		Executive	Officer	and		Chief
		Investment	Officer,	Soros	Fund
		Management	LLC;			Member,
		Advisory		Board	and	Investment
		Committee of the Open Society
		Foundations'	Economic			Justice
		Programme; Member	of	Advisory
		Council,		The		Bretton			Woods
		Committee
Mary Francis	Non-Executive Director	Non-Executive	Director,		BBPLC;
		Senior		Independent			Director,
		PensionBee Group PLC; Member, UK
		Takeover	Appeal	Board;	Senior
		Advisor, Chatham House
Crawford Gillies	Non-Executive Director	Chairman, Barclays Bank UK PLC;
		Chairman,	Edrington			Group;
		Chairman, Pitlochry Festival Theatre
Brian Gilvary	Senior Independent Director	Chairman, INEOS Energy, an INEOS
	and Non- Executive Director	group company; Chairman, The Royal
		Navy and Royal Marines Charity;
		Non-Executive Director, The Royal
		Navy;		Member,			Trilateral
		Commission;		Non-Executive
		Director, The Francis Clark Institute
Diane Schueneman	Non-Executive Director	Non-Executive	Director,		BBPLC;
		Non-Executive Director, Barclays US

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		LLC; Chair, Barclays Execution
		Services Limited
Julia Wilson	Non-Executive Director	Chair, The 100 Group of FTSE 100
		Finance Director"

* Subject to regulatory approval.

1. ; and

2. replace the sub-section entitled "Significant/Material Change" under the section entitled "General Information" commencing on page 167 of the Base Prospectus with the following:
   "There has been no material adverse change in the prospects of the Issuer or the Group since 31 December 2021, nor any significant change in the financial position or financial performance of the Issuer or the Group since 30 September 2022.".

IMPORTANT NOTICES

The Issuer accepts responsibility for the information contained in this Supplement and declares that, to the best of its knowledge, the information contained in this Supplement is in accordance with the facts and this Supplement makes no omission likely to affect its import.

To the extent that there is any inconsistency between (a) any statement in this Supplement or any statement incorporated by reference into the Base Prospectus by this Supplement and (b) any other statement in, or incorporated by reference into, the Base Prospectus, the statements in (a) above will prevail.

Save as disclosed in this Supplement, no significant new factor, material mistake or material inaccuracy relating to the information included in the Base Prospectus which is capable of affecting the assessment of the Notes issued under the Programme has arisen or been noted, as the case may be, since the publication of the Base Prospectus.

Any information contained in the documents specified above which is not incorporated by reference in the Base Prospectus is either not relevant for prospective investors for the purposes of Article 6(1) of the UK Prospectus Regulation or is covered elsewhere in the Base Prospectus.

If documents which are incorporated by reference into this Supplement themselves incorporate any information or other documents therein, either expressly or implicitly, such information or other documents will not form part of this Supplement for the purposes of the UK Prospectus Regulation except where such information or other documents are specifically incorporated by reference into this Supplement.

This Supplement shall be available on or around the date hereof in electronic form at https://www.londonstockexchange.com/exchange/news/market-news/market-news-home.html.

27 October 2022

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