Astellas Pharma Inc. announced that at a meeting of its Board of Directors approved changes of its Representative Director, President and CEO and its management structure. Naoki Okamura will take over as Representative Director, new President and CEO with Kenji Yasukawa to be Representative Director, Chairman of the Board Effective April 1, 2023 Claus Zieler will be appointed as CCO. He joined Astellas Group in 2019 as President, International Markets Commercial with experience in the commercial area at Schering and Bayer.

He was appointed as President, Established Markets Commercial in January 2022. Together with Yukio Matsui, the current CCO, he has been implementing several imperative changes with his strong driving force and patient centric mindset. Adam Pearson will be appointed as CStO.

Since joining Astellas Group (former Yamanouchi Group) in 2004 after working at Boston Consulting Group, He has held various positions including Regional Senior Vice President, North Europe, Astellas Pharma Europe Ltd. and General Manager, United Kingdom, Astellas Pharma Ltd., and since 2020 has been Division Head of Corporate Strategy, leading the development and promotion of CSP2021. Yukio Matsui, the current CCO, will retire on March 31, 2023. Yukio Matsui, the current Senior Corporate Executive (Senmu Tantou-Yakuin), will retire on March 31, 2023.

Minoru Kikuoka will be Corporate Executive Vice President (Fukusyacho Tantou-Yakuin)effective April 1, 2023. NIKKON Holdings Co.,Ltd. Kenji Yasukawa Date of Birth: June 7, 1960 Place of Birth: Tokyo - Career History April 2018 Representative Director, President and CEO, the Company (present post) June 2017 Representative Director, Executive Vice President, Chief Strategy Officer and Chief Commercial Officer, the Company April 2017 Senior Corporate Executive, Senior Vice President, Chief Strategy Officer and Chief Commercial Officer, the Company June 2012 Senior Corporate Executive, Senior Vice President and Chief Strategy Officer, the Company April 2012 Corporate Executive, Senior Vice President and Chief Strategy Officer, the Company April 2011 Corporate Executive, Vice President, Product & Portfolio Strategy, the Company October 2010 Corporate Executive of the Company, Therapeutic Area Head, Urology, Astellas Pharma Global Development Inc. June 2010 Corporate Executive of the Company, Therapeutic Area Head, Urology, Astellas Pharma Europe B.V. April 2005 Vice President, Project Management, Urology, the Company April 1986 Joined the Company (former Yamanouchi Pharmaceutical Co. Ltd.) - Education July 2001 Showa University Graduate School of Pharmaceutical Sciences, Japan, Ph.D. in Pharmaceutical Sciences March 1986 University of Tokyo, Master of Science, Agriculture Naoki Okamura Date of Birth: September 18, 1962 Place of Birth: Shizuoka Prefecture - Career History: April 2022 Representative Director, Executive Vice President and Chief Strategy Officer (CStO), the Company (present post) March 2022 Representative Director, Executive Vice President, Chief Strategy Officer and Chief Business Officer (CStO and CBO), the Company September 2021 Representative Director, Executive Vice President, Chief Strategy Officer, Chief Financial Officer and Chief Business Officer (CStO & CFO, and CBO), the Company October 2019 Representative Director, Executive Vice President, Chief Strategy Officer and Chief Financial Officer, (CStO & CFO), the Company June 2019 Representative Director, Executive Vice President, Chief Strategy Officer (CStO), the Company April 2019 Corporate Executive Vice President, Chief Strategy Officer (CStO), the Company April 2018 Corporate Executive, Chief Strategy Officer (CStO), the Company June 2016 Corporate Executive, Vice President, Corporate Planning, the Company April 2016 Vice President, Corporate Planning, the Company July 2014 Vice President, Licensing & Alliances, the Company April 2012 Senior Vice President, Chief Strategy Officer, Astellas Pharma Europe Ltd. October 2010 President & CEO, OSI Pharmaceuticals Inc. April 1986 Joined the Company - Education March 1985 University of Tokyo, Faculty of Pharmacy Claus Zieler - Career History: January 2022 President, Established Markets Commercial, Astellas Pharma Europe Ltd.(Present post) October 2019 President, International Markets Commercial, Astellas Pharma Singapore Pte Ltd. June 2015 Senior Vice President, Pharmaceuticals Region Asia Pacific, Bayer (South East Asia) Pte Ltd. October 2011 Operating Officer and Head of BU Cardiovascular & Neurology,Bayer Yakuhin Ltd. March 2007 General Manager HealthCare Belgium /Luxemburg, Bayer SA-NV Marsh 2005 General Manager Argentina, Schering Argentina May 2003 Vice President Business Development, Schering Berlin Inc. May 1995 Regional Product Manager for Latin America, Schering AG Adam Pearson - Career History: April 2022 Executive Vice President, Corporate Strategy.

Astellas Pharma Inc. (Present post) April 2020 Senior Vice President, Corporate Planning, Astellas Pharma Inc. April 2019 General Manager, United Kingdom, Astellas Pharma Ltd. July 2016 Regional Senior Vice President, North Europe, Astellas Pharma Europe Ltd. February 2011 General Manager, South East Europe, Astellas Pharma d.o.o. January 2007 Sales Director Netherlands, Astellas Pharma Netherlands, BV. January 2004 Director of Strategic Planning, Europe, Yamanouchi Europe Ltd. September 1994 Consultant & Project Leader, Boston Consulting Group.