Aldeyra Therapeutics, Inc. provided an update on its Phase 3 clinical programs in noninfectious anterior uveitis and Sjögren-Larsson Syndrome. Based on meetings held with the U.S. Food and Drug Administration (FDA) in 2016 and 2017, Aldeyra expects to initiate enrollment, in the second quarter of 2017, of the first-ever vehicle-controlled Phase 3 clinical trial in noninfectious anterior uveitis (NAU). The trial is expected to enroll up to 100 patients, randomized equally to topical ocular ADX-102 or vehicle treatment for four weeks. Consistent with other NAU clinical trials, the primary endpoint is the clearing of inflammatory cells in the anterior chamber of the eye. Data from the trial are expected in late 2018. NAU is a rare and serious ocular disorder that can lead to blindness, and is often treated with corticosteroids, which can lead to significant ocular toxicities, including cataracts, elevation of intraocular pressure and glaucoma, and infection. In May 2016, Aldeyra announced Phase 2 data demonstrating that ADX-102, Aldeyra's lead compound, was at least as effective as a corticosteroid in treating NAU. Importantly, ADX-102 did not lead to the elevation of intraocular pressure observed in the corticosteroid group of patients. Sjögren-Larsson Syndrome: Based on an End of Phase 2 meeting with the FDA, Aldeyra plans to initiate enrollment, in the second half of 2017, of the first-ever Phase 3 clinical trial in Sjögren-Larsson Syndrome (SLS). The proposed clinical trial is expected to enroll up to 30 SLS patients in the United States and Europe. All patients will be treated with topical dermal ADX-102 for at least four months. The primary endpoint will be the severity of the dermatologic disease. Data from the trial are expected in 2019. SLS is a rare genetic condition characterized in part by ichthyosis, a serious dermatologic condition that causes significant morbidity, including bleeding and social stigma. There are no FDA-approved therapies indicated for the treatment of SLS. In August 2016, Aldeyra announced Phase 2 data demonstrating that topical dermal ADX-102 was statistically superior to vehicle in improving ichthyosis in SLS patients.