4DMedical Limited announced that the first clinical pilot for XV Lung Ventilation Analysis Software will be conducted at St. Joseph Hospital located in Orange County, California, U.S. The clinical pilot represents the first clinical usage of XV LVAS on patients in the U.S. and will be used to aid hospital physicians to screen for a variety of lung conditions, including asthma, emphysema, pulmonary fibrosis, lung cancer and COVID-19. As part of the pilot, St. Joseph Hospital will conduct a full review of 4DMedical's end-to-end solution over the coming months. The clinical pilot signifies the commencement of the Company's commercialization phase in the U.S. as patients start to receive XV LVAS scans as part of standard clinical practice, in both inpatient and outpatient settings. Clinical pilots will form an important part of the commercial rollout of XV LVAS in the U.S., allowing hospitals and medical institutions to implement and trial 4DMedical's end-to-end solution ahead of potential commercial integration. The clinical pilot with St. Joseph Hospital follows on from XV LVAS receiving FDA 510(k) clearance in May 2020, as well as Class 1 regulatory approval from the Australian Therapeutic Goods Administration (TGA) in September 2020, enabling 4DMedical to sell and market XV LVAS in the U.S. and Australia respectively. As previously announced to the ASX on 18 December 2020, the first commercial scans have already been conducted in Australia. Supported by more than 15 years of development in Australia and using the Company's XV Technology platform, XV LVAS improves the capacity of physicians to diagnose and treat patients with respiratory diseases more efficiently, by providing objective measurements of regional lung motion and air flow. Importantly, XV LVAS has been validated to monitor Acute Respiratory Distress Syndrome (ARDS), a respiratory condition caused by COVID-19, as part of its FDA 510(k) clearance and has the potential to be used to accelerate therapy research and assess the effectiveness of potential treatments. With over 20% of the global COVID-19 cases currently located in the U.S., 4DMedical and St. Joseph Hospital will work together to provide relevant assessment scans to current and past COVID-19 patients.