April 30 (Reuters) - Wall Street's main indexes opened lower on Tuesday after stronger-than-expected labor costs signaled persistent inflationary pressures, while caution prevailed ahead of the Federal Reserve's interest rate decision.

The Dow Jones Industrial Average fell 48.7 points, or 0.13%, at the open to 38,337.4. The S&P 500 fell 12.4 points, or 0.24%, at the open to 5,103.78, while the Nasdaq Composite dropped 62.2 points, or 0.39%, to 15,920.886 at the opening bell. (Reporting by Shristi Achar A in Bengaluru; Editing by Devika Syamnath)