The board of YiChang HEC ChangJiang Pharmaceutical Co., Ltd. has received the written resignations tendered (``Mr. Zhao''), an independent non-executive Director, with effect from 20 September 2022. Mr. Huang resigned from his positions as a non-executive Director and a member of the nomination committee of the Board (the ``Nomination Committee'') due to his other business commitments. Mr. Zhao resigned from his positions as an independent non- executive Director, the chairman of the Nomination Committee and a member of the audit committee of the Board (the ``Audit Committee'') due to his other business commitments.

Each of Mr. Huang and Mr. Zhao confirmed that he has no disagreement with the Board.