ASCO 2022 Investor Breakfast
June 5, 2022
Agenda
- Introductions and Brief Overview of Tempest
- TPST-1120
Mark Yarchoan, M.D.
Associate Professor of Oncology
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
- TPST-1495
Susanna V. Ulahannan, M.D., MMEd
Assist. Professor of Medicine, Stephenson Cancer Center, the Univ. of Oklahoma Associate Dir, Oklahoma TSET Phase 1 Program
- TREX1
Jason J. Luke, M.D., FACP Associate Professor
Director of the Cancer Immunotherapeutics Center, Univ. of Pittsburgh School of Medicine
- Q&A
Drs. Yarchoan, Ulahannan and Luke to be joined by:
Toni K. Choueiri, M.D.
Director, Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute Jerome and Nancy Kohlberg Chair and Professor of Medicine,
Harvard Medical School
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Information Regarding Disclosures
Forward-Looking Statements
This presentation contains forward-looking statements (including within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended (the "Securities Act")) concerning Tempest Therapeutics, Inc. ("Tempest Therapeutics"). These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Tempest Therapeutics, as well as assumptions made by, and information currently available to, management of Tempest Therapeutics. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as "may," "will," "should," "would," "could", "expect," "anticipate," "plan," "likely," "believe," "estimate," "project," "intend," and other similar expressions. Statements that are not historical facts are forward-looking statements. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: our strategies, prospects, plans, expectations or objectives for future operations; the progress, scope or timing of the development of our product candidates; the benefits that may be derived from any future products or the commercial or market opportunity with respect to any of our future products; our ability to protect our intellectual property rights; our anticipated operations, financial position, ability to raise capital to fund operations, revenues, costs or expenses; statements regarding future economic conditions or performance; statements of belief and any statement of assumptions underlying any of the foregoing. Many of these risks are described in greater detail in the Form 10-Q filed by Tempest Therapeutics with the Securities and Exchange Commission on May 13, 2022.
Except as required by applicable law, Tempest Therapeutics undertakes no obligation to revise or update any forward- looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.
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First-in-Class* Oncology Pipeline with Broad Potential
TPST-1120
PPARα
Antagonist
TPST-1495
Dual EP2/4
Antagonist
TREX-1
Inhibitor
Novel Target
STAGE OF DEVELOPMENT | ||||||||||||
Indication(s) | Research | IND-Enabling | Phase 1 | Phase 2 | Initiation1 | |||||||
✓ | ||||||||||||
Multiple Solid Tumors | Monotherapy dose finding | Completed | ||||||||||
Combination PD-1 dose finding | ||||||||||||
HCC/RCC/CCA | Ongoing | |||||||||||
HCC | Frontline triplet combination (randomized)2 | Ongoing | ||||||||||
Monotherapy dose finding | ||||||||||||
Multiple Solid Tumors | Ongoing | |||||||||||
Combination PD-1 dose finding | ||||||||||||
Multiple Solid Tumors | Ongoing | |||||||||||
Combination PD-1 expansion(s) | ||||||||||||
Targeted Populations3 | 2H 2022 | |||||||||||
Targeted Populations4 | Monotherapy expansion(s) | 2H 2022 | ||||||||||
Solid Tumors | Lead Op | Ongoing | ||||||||||
Oncology | Ongoing | |||||||||||
"HCC" hepatocellular carcinoma, "RCC" renal cell carcinoma, "CCA" cholangiocarcinoma
* If approved by FDA 1 Timing is an estimate based on current projections. 2Pursuant to a collaboration with Roche; TPST retains all product rights. 3 Study could be either | |
a single indication or biomarker-based basket 4 With additional funding, monotherapy expansion(s) would be in select indications based on target expression and/or a | 4 |
biomarker-positive basket cohort; |
TPST-1120
PPAR Antagonist
Mark Yarchoan, M.D.
Associate Professor of Oncology
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
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Tempest Therapeutics Inc. published this content on 05 June 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 06 June 2022 07:51:05 UTC.