Item 8.01 Other Events.

On December 14, 2022, the Board of Directors of Sio Gene Therapies Inc. (the "Company") unanimously approved the dissolution and liquidation of the Company pursuant to a plan of complete liquidation and dissolution (the "Plan of Dissolution"), subject to shareholder approval. The Company intends to call a special meeting of the shareholders to seek approval of the Plan of Dissolution and will file proxy materials relating to the special meeting with the Securities and Exchange Commission as soon as practicable. A copy of the Plan of Dissolution is filed herewith as Exhibit 2.1 and incorporated herein by reference.

A copy of the press release issued by the Company on December 14, 2022 announcing, among other things, the Board of Directors' approval of the Plan of Dissolution is filed herewith as Exhibit 99.1 and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.



(d) Exhibits.

    Exhibit
    Number                                         Description of Document

      2.1               Plan of Complete Liquidation and Dissolution of Sio Gene Therapies Inc.

     99.1               Press Release of Sio Gene Therapies Inc., dated     Dec    ember 1    4    ,
                      2022, "Sio Gene Therapies Announces     Plan of Complete Liquidation and
                      Dissolution    "

      104             Cover Page Interactive Data File (embedded within the Inline XBRL document)

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