Cancellation of listing and admission to trading of Shire plc
U.S.$1,100,000,000 2.75 per cent. Convertible Bonds due 2014 with ISIN:
XS0299687482 (the "Bonds")

January 17, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
that, further to the receipt by the Company of bondholder conversion notices in
respect of Bonds in the aggregate principal amount of U.S.$1,099,050,000, the
redemption of Bonds in the aggregate principal amount of U.S.$950,000 and the
announcement made by the Company on December 16, 2013, the listing of the Bonds
on the Official List of the UK Listing Authority and the admission of the Bonds
to trading on the Professional Securities Market of the London Stock Exchange
is hereby cancelled with effect from the date of this announcement.

For further information please contact:

Investor Relations

Eric Rojas                              erojas@shire.com     +1 781 482 0999

Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal and
Internal Medicine and we are developing treatments for symptomatic conditions
treated by specialist physicians in other targeted therapeutic areas.

www.shire.com

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

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