PreveCeutical Medical Inc. provide an update on its dual gene therapy program, an important and fundamental aspect of which involves the design, synthesis and screening of small interfering RNA (siRNA) constructs in downregulating the Company's target gene of interest, in type 2 diabetes and obesity. The design process involves strategic interchanging of individual nucleic acids across over 20 positions within regions of interest in the siRNA. The first series of siRNA constructs derived from this process were subsequently synthesised, purified and assessed for their ability to reduce expression of the Company's target gene in disease-specific cell-based models. Through this meticulous process PreveCeutical has identified no less than four novel siRNA constructs each of which preferentially targets the gene of interest, while reducing its expression by no less than 80% compared to a random siRNA (control) sequence. This is an important development setting the Company on the path to create a series of lead siRNA constructs, with the goal of employing innovative design strategies, which enhance their gene targeting specificity and biostability, while maintaining their exceptional gene silencing capacity.