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In vitro study reveals the antibodies elicited by the Pfizer-BioNTech COVID-19 vaccine, BNT162b2, can effectively neutralise the highly transmissible strains of SARS-CoV-2 with the N501Y mutation.
The results of the study conducted by
Two rapidly spreading SARS-CoV-2 strains have been reported, initially in the
To determine whether the immune response induced by the BNT162b2 vaccine can neutralise SARS-CoV-2 particles with the N501Y mutation, sera from 20 participants of the Phase III vaccine trial was administered to a virus with this substitution generated in UTMB's laboratory. According to the investigators, the sera neutralised the mutated virus as well as it neutralised the virus without the mutation.
The companies and UTMB said they are "encouraged" by these early, in vitro study findings, but that further data would be needed to monitor the vaccine's effectiveness in preventing COVID-19 caused by new virus variants. If the virus mutates such that an update to the vaccine is required to continue to confer protection against COVID-19, they said that they believe the flexibility of
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