OSE: treatment prospects with therapeutic mRNA
Results show that its therapeutic mRNA using a lipid nanoparticle vector enables selective delivery and local expression of the immunosuppressive cytokine IL-35 in the liver.
Another finding is that IL-35 therapeutic mRNA can suppress chronic and acute hepatic autoimmune inflammation in various preclinical mouse models by inhibiting B and T cell activation.
Finally, specific inhibition of autoantibodies was observed after treatment with IL-35 mRNA therapeutics in an inflammatory model of chronic hepatitis.
From OSE's point of view, these results open up treatment prospects, particularly in autoimmune hepatitis, a serious inflammatory and immune disorder of the liver with a significant unmet medical need.
These data were presented as a poster at the FOCIS (Federation of Clinical Immunology Societies) annual meeting currently taking place in San Francisco.
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