Merck : Announces Research Collaboration with Domain Therapeutics in Immuno-Oncology

• Companies to co-develop adenosine receptor antagonists, exploring their potential in immuno-oncology
• Merck to gain worldwide rights for Domain Therapeutics' next generation of adenosine receptor antagonists, complementing Merck's existing immuno-oncology pipeline

Darmstadt, Germany, January 23, 2017 - Merck, a leading science and technology company, today announced it has entered into a collaboration and licensing agreement with Domain Therapeutics, Strasbourg, France, to explore the potential of adenosine inhibition in the development of novel immuno-oncology agents. This collaboration strengthens our combination strategy in immuno-oncology, and underscores Merck's science-driven approach to discovering and developing novel compounds through both internal capabilities and external collaborations.

"This new generation of adenosine receptor antagonists are an important addition to our immuno-oncology pipeline," said Laszlo Radvanyi, Senior Vice President, Head of Research in Immuno-Oncology at the biopharma business of Merck. "We plan to explore the promise of adenosine receptor antagonists and develop novel compounds to potentially use in new combination immunotherapies for cancer."
Adenosine receptor antagonists are small molecules thought to slow tumor progression and improve the response to combination immunotherapies by inhibiting adenosine - a compound generated by cancer cells that inhibits anti-tumor responses by binding to T cells.

The agreement will involve a close collaboration between Merck and Domain Therapeutics to develop and test new agents targeting key adenosine receptors. Merck will support research activities and gain worldwide rights to Domain Therapeutics' next generation of adenosine receptor inhibitors.

"With its growing portfolio of immuno-oncology agents, Merck is the ideal partner to develop our adenosine programs," said Pascal Neuville, CEO,
Domain Therapeutics. "As a strong collaborator with a leading investigational checkpoint inhibitor, we are confident that through Merck, our programs will progress rapidly."

Merck is committed to exploring an array of targets, and taking creative scientific approaches to developing novel therapies for hard-to-treat cancers. The strength of Merck's promising oncology development program and growing presence in the immunotherapy space demonstrates how the company is re-imagining the way cancer care is delivered.

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For further information and press materials on Merck's activities in oncology, please visithttp://www.merckgroup.com/media-center-oncology.