Adlai Nortye Ltd. announced that it has entered into a clinical collaboration with Merck (known as MSD outside the US and Canada) to evaluate the combination of Adlai Nortye's AN0025 (EP4 Antagonist) and Merck's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), in patients with solid tumors. Under the terms of the agreement, Adlai Nortye and Merck will collaborate in a clinical trial to evaluate the safety and preliminary efficacy of the combination of AN0025 (EP4 Antagonist) and KEYTRUDA in patients with solid tumors. AN0025 (EP4 Antagonist) is an investigational, potentially first-in-class oral EP4 antagonist that in preclinical models prevents the binding of prostaglandin E2 to its EP4 receptor to change the immunosuppressive character of the tumor microenvironment. Based on preliminary results, it is well tolerated in patients with solid tumors. A Phase 1b combination study with radiotherapy and chemoradiotherapy is ongoing.