TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi                                                               
                                                                                                                  
    1. Identity of the issuer or the underlying issuer                   Keystone Investment Trust plc            
    of existing shares to which voting rights are                                                                 
    attached: ii                                                                                                  
                                                                                                                  
    2. Reason for the notification (please tick the appropriate box or boxes):                                    
                                                                                                                  
    An acquisition or disposal of voting rights                                                          X        
                                                                                                                  
    An acquisition or disposal of qualifying financial instruments which may result                               
    in the acquisition of shares already issued to which voting rights are attached                               
                                                                                                                  
    An acquisition or disposal of instruments with similar economic effect to                                     
    qualifying financial instruments                                                                              
                                                                                                                  
    An event changing the breakdown of voting rights                                                              
                                                                                                                  
    Other (please                                                                                                 
    specify):                                                                                                     
                                                                                                                  
    3. Full name of person(s) subject to the                                                                      
    notification obligation: iii                                                             RATHBONE BROTHERS PLC
                                                                                                                  
    4. Full name of shareholder(s)                                                                                
     (if different from 3.):iv                                                               RATHBONE BROTHERS PLC
                                                                                Rathbone Investment Management Ltd
                                                                                                                  
    5. Date of the transaction and date on                                                        5th January 2016
    which the threshold is crossed or                                                                             
    reached: v                                                                                                    
                                                                                                                  
    6. Date on which issuer notified:                                                             7th January 2016
                                                                                                                  
    7. Threshold(s) that is/are crossed or                                                                Under 5%
    reached: vi, vii                                                                                              
                                                                                                                  
    8. Notified details:                                                                                          
                                                                                                                  
    A: Voting rights attached to shares viii, ix                                                                  
                                                                                                                  
    Class/type of   Situation previous         Resulting situation after the triggering transaction               
    shares          to the triggering                                                                             
                    transaction                                                                                   
    if possible                                                                                                   
    using           Number         Number      Number      Number of voting       % of  voting rights x           
    the ISIN CODE   of             of          of shares   rights                                                 
                    Shares         Voting                                                                         
                                   Rights      Direct      Direct xi    Indirect  Direct      Indirect            
                                                                        xii                                       
                                                                                                                  
    50p Ord Shares  746,300        746,300     675,813     N/A          337,907   N/A         4.999%              
                                                                                                                  
    GB0004912068                                                                                                  
                                                                                                                  
    B: Qualifying Financial Instruments                                                                           
                                                                                                                  
    Resulting situation after the triggering transaction                                                          
                                                                                                                  
    Type of financial         Expiration Exercise/                   Number of voting       % of voting             
    instrument                         Conversion Period xiv       rights that may be     rights                  
                              date                                 acquired if the                                
                              xiii                                 instrument is                                  
                                                                   exercised/ converted.                          
                                                                                                                  
    C: Financial Instruments with similar economic effect to Qualifying Financial                                 
    Instruments xv, xvi                                                                                           
                                                                                                                  
    Resulting situation after the triggering transaction                                                          
                                                                                                                  
    Type of financial  Exercise    Expiration Exercise/          Number of voting rights % of voting rights          
    instrument         price       date    Conversion period  instrument refers to    xix, xx                     
                                   xvii    xviii                                                                  
                                                                                                                  
                                                                                      Nominal         Delta       
                                                                                                                  
                                                                                                                  
                                                                                                                  
    Total (A+B+C)                                                                                                 
                                                                                                                  
    Number of voting rights                             Percentage of voting rights                               
                                                                                                                  
    675,813                                             4.999%                                                    
                                                                                                                  

       

    9. Chain of controlled undertakings through which the voting rights and/or the              
    financial instruments are effectively held, if applicable: xxi                              
                                                                                                
    RATHBONE BROTHERS PLC*                                                                      
                                                                                                
    Rathbone Investment Management Ltd                                                          
                                            4.99906%                                            
                                                                                                
    * Rathbone Brothers Plc is the holding company of the above                                 
                                                                                                
    Proxy Voting:                                                                               
                                                                                                
    10. Name of the proxy holder:                                                               
                                                                                                
    11. Number of voting rights proxy holder will cease                                         
    to hold:                                                                                    
                                                                                                
    12. Date on which proxy holder will cease to hold                                           
    voting rights:                                                                              
                                                                                                
                                                 Total voting rights used as a denominator:     
    13. Additional information:                                                                 
                                                 6,759,399                                      
                                                                                                
    14. Contact name:                                                                           
                                                 Nira Mistry                                    
                                                                                                
    15. Contact telephone number:                                                               
                                                 020 3753 0691