2021 Investor Day

December 9, 2021

Nasdaq: IONS

2021 INVESTOR DAY

Participating in Today's Presentation

  • There will be one Q&A session at the end of today's program
  • Submit questions in the "Ask a Question" field and click send
  • A replay will be available on the Investors page of the Ionis website later today
  • Today's slides may be downloaded from the Investors section of the Ionis website under Events
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Forward-Looking Statements

This presentation includes forward-looking statements regarding our business, financial guidance and the therapeutic and commercial potential of SPINRAZA® (nusinersen), eplontersen, olezarsen, donidalorsen, Ionis' technologies, and Ionis' other products in development. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward- looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, including those related to the impact COVID-19 could have on our business, and including but not limited to those related to our commercial products and the medicines in our pipeline, and particularly those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward- looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2020 and our most recent Form 10-Q quarterly filing, which are on file with the SEC. Copies of this and other documents are available at www.ionispharma.com.

In this presentation, unless the context requires otherwise, "Ionis," "Company," "we," "our," and "us" refers to Ionis Pharmaceuticals and its subsidiaries.

Ionis Pharmaceuticals™ is a trademark of Ionis Pharmaceuticals, Inc. Akcea Therapeutics® is a registered trademark of Akcea Therapeutics, Inc. TEGSEDI® is a trademark of Akcea Therapeutics, Inc. WAYLIVRA® is a registered trademark of Akcea Therapeutics, Inc. SPINRAZA® is a registered trademark of Biogen.

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Building a Leading Biotechnology Company

Brett Monia, Ph.D.

Chief Executive Officer

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Company Presenters

Brett Monia, Ph.D.

Sam Tsimikas, M.D.

Onaiza Cadoret

Chief Executive Officer

SVP, Global Cardiovascular Development

Chief Corp. Dev. & Commercial Officer

Kenneth Newman, M.D.

Eric Swayze, Ph.D.

Beth Hougen

VP, Clinical Development

EVP, Research

Chief Financial Officer

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Ionis Pharmaceuticals Inc. published this content on 09 December 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 09 December 2021 16:51:10 UTC.