Geneos is focused on developing DNA-based, neoantigen-targeting personalized cancer immunotherapies. Starting with receipt of seed plasmid DNA from Geneos, the VGXI team achieved a record-setting timeline of 5 days from host cell transformation to filled drug product manufacturing, and less than 2 weeks from transformation to release and shipment of the patient's first dose. Overall, these timelines are a fraction of the 6 to 8 month turnaround time for GMP plasmid DNA that is standard in the industry, and they have been accomplished while maintaining the exceptional product quality for which VGXI is well known.
'Decades of experience and optimization of VGXI's established, proprietary methods for DNA plasmid purification have allowed us to support the unique requirements of our client's project.'
VGXI's efforts represent a critical element of Geneos' integrated GT-EPIC platform. Geneos has established a broad collaboration created specifically to achieve the rapid biopsy-to-treatment turnaround times needed for personalized cancer therapies. The full GT-EPIC platform includes patient tumor exome/transcriptome sequencing and identification of the relevant neoantigen targets followed by neoantigen vaccine design, synthesis of the seed plasmid DNA, vaccine manufacture, and final delivery of the personalized neoantigen vaccine - with all platform elements executed within an overall timeline of 6 - 8 weeks. The patient specific GMP product lots manufactured under the VGXI supply agreement will support Geneos' previously announced GT-30 clinical trial focused on the treatment of patients with advanced hepatocellular cancer.
Dr.
ABOUT VGXI, INC.
ABOUT
ABOUT GENEOS THERAPEUTICS
At Geneos Therapeutics, we believe that personalized therapies are the future of cancer treatment. Our passion is to develop personalized therapies to unleash the most powerful force against cancer - your body's own immune system. Our approach using our GT-EPIC platform is to target unique neoantigens (abnormal mutations produced by cancer cells) from individual patient tumors to develop novel treatments for cancer. We have an experienced management team with a track record of success in building immunotherapy-based companies. Geneos was created as a spinout of
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