NOTRE DAME INTERMÉDICA PARTICIPAÇÕES S.A.

Corporate ID No. 19.853.511/0001-84

Listed on the B3 Stock Exchange

MATERIAL FACT

BUSINESS COMBINATION BETWEEN GNDI AND HAPVIDA:

CADE FINAL APPROVAL

Notre Dame Intermédica Participações S.A. ("Company"), in addition to the Material Facts disclosed on January 8, 2021, February 15, 2021, February 27, 2021, March 29, 2021 and December 15, 2021 regarding the business combination between the Company and Hapvida Participações e Investimentos S.A. ("Transaction"), hereby informs its shareholders and the market in general that, 15 days elapsed since the publication of Order SG No. 1854/2021 ("Order") in the Union's Official Gazette of December 16, 2021 without no third-partyappeal or summon by the members of the Court of the Administrative Council for Economic Defense ("CADE"), was issued on this date the unappealable transit certificate of the final decision of the General Superintendence of CADE that approved the Transaction without restrictions.

The Company will work together with Hapvida Participações e Investimentos S.A. on a schedule of steps to be completed until the final closing of the Transaction.

The Company will keep its shareholders and the market informed of subsequent facts related to the Transaction, pursuant to the law and CVM regulations.

São Paulo, January 4, 2022.

Glauco Desiderio

Investor Relations Officer

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Notre Dame Intermédica Participações SA published this content on 04 January 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 04 January 2022 16:48:09 UTC.