Gracell Biotechnologies
Pioneering the Next Generation of CAR-T Cell Therapies
Corporate Presentation | AUGUST 2022
NASDAQ:GRCL I gracellbio.com
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This presentation has been prepared by Gracell Biotechnologies Inc. (the "Company") solely for information purpose and has not been independently verified. By viewing or accessing the information contained in this presentation, the recipient hereby acknowledges and agrees that no representations, warranties or undertakings, express or implied, are made by the Company or any of its directors, shareholders, employees, agents, affiliates, advisors or representatives as to, and no reliance should be placed upon, the accuracy, fairness, completeness or correctness of the information or opinions presented or contained in this presentation. None of the Company or any of its directors, shareholders, employees, agents, affiliates, advisors or representatives accept any responsibility whatsoever (in negligence or otherwise) for any loss howsoever arising from any information presented or contained in this presentation or otherwise arising in connection with the presentation. The information presented or contained in this presentation speaks as of the date of this presentation and is subject to change without notice.
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Investment Highlights
Proprietary Cell Therapy Platforms
- FasTCAR - Next-day manufacturing, a gamer-changer for autologous CAR-T
- TruUCAR - Novel, elegant design to enable off-the-shelf allogeneic CAR-T
Rich Pipeline of Breakthrough CAR-T Candidates
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Five clinical stage candidates
o Two China IND studies and three IIT studies
o Two product candidates in three indications presented at ASCO and EHA 2022 o Plan to file INDs in U.S. and China - Five preclinical candidates
o In both hematological cancers and solid tumors
Strong Financial Position to Fund R&D Pipeline
- Cash position of $267.3 million as of 3/31/2022 o Well-fundedwith cash runway into 2024
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Experienced Leadership Team
William Cao, Ph.D., B.M.
Founder, Chairman & CEO
- 30+ years of biotech and R&D experience
- Co-founderand former CEO of Cellular BiomedicinepiGroup
- 80+ issued patents & applications for advanced cell therapies
Wendy Li, M.D.
Chief Medical Officer
- 20+ years of experience leading all critical aspects of clinical development and medical affairs
- Over 30 successful IND, NDA and BLA filings
Kevin Xie, Ph.D., M.B.A.
Chief Financial Officer
- 20+ years of experience in healthcare investment and corporate leadership
- President and global portfolio manager of Fosun Healthcare Holdings
Samuel Zhang, Ph.D.
Chief Business Officer
- 20+ years of experience in business development, corporate strategy, and pharmaceutical commercialization
- CBO of NeoImmuneTech
Jenny Ni, M.D., Ph.D.
Chief Technology Officer
- 25+ years of experience in gene & cell therapy, vaccine and contract manufacturing
- Led CMC development of five IND filings / approvals for hematological and solid malignancies
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Proprietary Technology Platforms and Enhancements
Technology platforms to improve treatment outcomes & overcome industry commercial bottlenecks
Autologous CAR-T Platform | Allogeneic CAR-T Platform | ||
• | Next-day manufacturing | • | Off-the-shelf availability |
• Younger T cells with enhanced fitness | • | Novel dual-directed CAR design to eliminate HvG | |
• | Fully-closed manufacturing capabilities | without need for extra immunosuppressive therapeutics |
Proprietary
technology toolkit to enhance platforms
Dual CAR
- Deep expertise in protein chemistry
- True dual-antigen targeting
- Leveraging a second CAR to reduce rejection
SMART CARTTM
2nd Gen Enhanced CAR for Solid tumors
- To overcome and take advantage of immunosuppressive tumor microenvironment
- Enhanced CAR-T cell proliferation and killing activities
- Resisting exhaustion with improved persistence of CAR-T cells
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Gracell Biotechnologies Inc. published this content on 01 August 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 01 August 2022 12:14:10 UTC.