Gentian Diagnostics : Plasma and serum calprotectin at IFCC EuroMedLab Munich 2022

Meet us at EuroMedLab to learn more about calprotectin in plasma and serum

We look forward to exhibit athe XXIV IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine EuroMedLab, in Munich in April 2022.

We hope to see you at our booth #201 to discuss measurement of calprotectin in plasma and serum in the assessment of inflammation and severe infection.

Biomarker for early detection of the inflammatory response to infections

Calprotectin is one of the earliest biomarkers for detection of the inflammatory response to infections^1,2. The biomarker is predominantly expressed in neutrophil granulocytes, and it is released upon neutrophil activation in response to inflammation and infection.

Discriminating between bacterial and viral infection Calprotectin has been reported as diagnostic marker in the discrimination between bacterial and viral infection³, in assessment of severe infections and sepsis^4-6and in the prediction for development of severe infections⁷. Interestingly, calprotectin has also been reported a risk marker in severe COVID-19^8,9, which in contrast to other viral infections induce a hyperinflammation response and pathways that mimic bacterial sepsis¹⁰.
Biomarker for non-infectious inflammatory diseases, like rheumatic diseases Calprotectin is also a highly valuable biomarker for non-infectious inflammatory diseases, like rheumatic diseases¹¹. In rheumatoid arthritis (RA) blood calprotectin has been reported to correlate with the inflammation in the arthritic joints and disease severity¹².

GCAL® - Plasma and serum calprotectin immunoassay

The Gentian Calprotectin Immunoassay (GCAL^®) is the first turbidimetric assay for the quantitative measurement of calprotectin in plasma and serum intended as an aid in the detection and assessment of inflammation. The open channel assay can be applied on a wide range of automated clinical chemistry analysers.

Get in touch for information and ordering

Interested in calprotectin for plasma and serum? Want to know more?Please send an email to [e-mail] fill out the form below:

References:

1. Fullerton J et al. Kinetics of calprotectin, procalcitonin and C-reactive protein in healthy volunteers administered intravenous endotoxin. 40th International Symposium on Intensive Care & Emergency Medicine. Critical Care. 2020. P474.
2. Jonsson N et al. Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessment. Crit Care Resusc. 2017.
3. Havelka A et al. Calprotectin, a new biomarker for diagnosis of acute respiratory infections. Sci Rep. 2020.
4. Larsson A et al. Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patients. Scand J Clin Lab Invest. 2020.
5. Jonsson et al. Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessment. Crit Care Resusc. 2017.
6. Simm M et al. Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study. Biomark Med. 2016.
7. Parke Å et al. Plasma-calprotectin compared with routine biomarkers for prediction of early severe event in sepsis. 40th International Symposium on Intensive Care & Emergency Medicine. Critical Care. 2020.
8. Bauer W et al. Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department. J Infect. 2021.
9. Luis García de Guadiana Romualdo et al. Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: A case series. J Infect. 2021.
10. Vincent JL. COVID-19: it's all about sepsis. Future Microbiol. 2021.
11. Ometto F et al. Calprotectin in rheumatic diseases. Exp Biol Med (Maywood). 2017.
12. Wang Q et al. The Role of Calprotectin in Rheumatoid Arthritis. J Transl Int Med. 2019.