On November 4, 2021, Vern Lee Schramm, Ph.D., provided notice to the Board of Directors of First Wave BioPharma, Inc. (the ?Company?), that he would not stand for re-election as director at the Company?s upcoming annual meeting of stockholders (the ?Annual Meeting?), currently scheduled for December 17, 2021. Dr. Schramm?s term as director will expire at the closing of the Annual Meeting. Dr. Schramm?s notice was not the result of any disagreement with the Company on any matters relating to the Company?s operations, policies or practices.