Eli Lilly and Company announced that results from the global Phase 3 REACH-2 study of CYRAMZA® (ramucirumab) as a single agent in the second-line treatment of people with AFP-High (alpha-fetoprotein =400 ng/mL) hepatocellular carcinoma (HCC) were published online in The Lancet Oncology. Data from REACH-2 are also being presented at the 2019 Gastrointestinal Cancers Symposium in San Francisco. HCC is also known as liver cancer, which is a leading cause of cancer-related death worldwide.1 In the U.S., liver cancer is one of the few major cancers with incidence rates that continue to rise every year2 and is the fastest rising cause of cancer death. REACH-2 showed a statistically significant improvement in the primary endpoint of overall survival (OS) as well as in the secondary endpoint of progression-free survival (PFS). The safety profile observed in the REACH-2 study was consistent with what has been previously observed for single-agent CYRAMZA in patients with HCC. Additionally, in a pooled analysis comprised of all AFP-High HCC patients across both the REACH-2 and REACH studies, CYRAMZA treatment also resulted in an improvement in median OS.REACH-2, the first positive Phase 3 HCC trial in a biomarker-selected patient population, evaluated the benefit of CYRAMZA treatment in AFP-High HCC patients who were intolerant to, or had disease progression while on or following treatment with, sorafenib. Approximately half of all advanced HCC patients are AFP-High, and these patients are among those with the poorest prognosis relative to the general HCC patient population.