Creative Medical Technology Holdings Inc. announced data identifying one of the primary mechanisms of action of its ImmCelz® product in the treatment of stroke. The Company reported that animals having previously been treated with ImmCelz® have an increase in what is called “endogenous neurogenesis”. This process allows for certain parts of the brain to heal themselves more effectively after injury, for example, such as in stroke. The stimulation of endogenous neurogenesis was approximately 85% higher than in animals treatment with a popular type of stem cell termed mesenchymal stem cells. Additionally, the Company reported that depletion of animals of T regulatory cells resulted in suppression of endogenous neurogenesis. In contrast to stem cell based approaches, ImmCelz® is an immunotherapy product in which stem cells are used to “educate” immune cells to endow them with regenerative activity. The Company believes that “educated” immune cells may be superior to stem cells because of their: a) ability to replicate and form “memory” cells; b) substantially smaller size, which allows for superior biodistribution than stem cells; and c) adeptness at surviving in conditions such as hypoxia or acidosis, which would inactivate stem cells.