Item 5.02. Departure of Directors or Certain Officers; Election of Directors;


           Appointment of Certain Officers; Compensatory Arrangements of Certain
           Officers.

On January 5, 2022, Mr. Joseph Vazzano notified Avenue Therapeutics, Inc. (the "Company") that he was resigning from his role as the Company's Chief Financial Officer, effective January 14, 2022, to pursue other opportunities. Mr. Vazzano did not resign as a result of any disagreement with the Company on any matter relating to the Company's operations, policies or practices.

In connection with Mr. Vazzano's resignation and transition to a consulting role, the Company entered into a consulting agreement with Mr. Vazzano dated January 7, 2022.

On January 7, 2022 the Company's Board of Directors appointed Dr. Lucy Lu, M.D., the Company's President and Chief Executive Officer, as the Company's interim Chief Financial Offier and Principal Financial Officer.

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