Item 1.02 Termination of a Material Definitive Agreement.

On May 2, 2023, Applied Molecular Transport Inc. (the "Company") entered into (i) the Third Amendment to Lease (the "Amendment") and (ii) an Agreement for Modification of Lease and Voluntary Surrender of Premises (the "Agreement" and together with the Amendment, the "Lease Termination Agreements") with ARE-East Jamie Court, LLC, a Delaware limited liability company ("Landlord") with respect to the Company's lease (the "Lease") of its headquarters at 450 East Jamie Court, South San Francisco, California (the "Premises"). The Amendment provides that the Lease with respect to the portion of the Premises consisting of the entire third floor terminated on March 31, 2023. The Agreement provides that the Lease with respect to the remainder of the Premises will terminate on the earlier of August 1, 2023 or such date that Landlord elects to terminate the Lease.

As consideration for Landlord's entry into the Agreement, the Company has agreed to: (a) pay to Landlord a lease modification payment of $5,380,000, (b) allow Landlord to draw upon the letter of credit it provided as a security deposit in the amount of $916,300 and (c) convey ownership to Landlord of certain items of personal property, furniture and fixtures located within the Premises. The Company will have no further rent obligations to Landlord pursuant to the Lease or Agreement from and after April 1, 2023.

The foregoing description of the Lease Termination Agreements do not purport to be complete and are qualified in their entirety by reference to the full text of the Lease Termination Agreements, copies of which will be filed with the Company's public filings and incorporated herein by reference.

Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an

Off-Balance Sheet Arrangement of a Registration

The information set forth in Item 1.02 of this Current Report on Form 8-K is incorporated by reference into this Item 2.03.

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