Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.



This Amendment to the Current Report on Form 8-K of Xenon Pharmaceuticals Inc. (the "Company"), filed with the U.S. Securities Exchange Commission on November 5, 2020 (the "Form 8-K"), relates to the appointment of Patrick Machado to the Company's Board of Directors (the "Board"). At the time of his appointment to the Board, no determination had been made regarding the committees of the Board on which Mr. Machado would serve. This Amendment is being filed to report Mr. Machado's committee appointment. No other disclosure in the Form 8-K is amended by this Amendment.

On January 12, 2021, the Board appointed Mr. Machado to the Company's Audit Committee, effective immediately. Following Mr. Machado's appointment, the members of the Audit Committee are Mr. Frank Holler (Chair), Mr. Steven Gannon, Mr. Patrick Machado, and Mr. Michael Tarnow.

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