Item 8.01 Other Events - Letter to Shareholders and Interested Parties.

Dear Shareholders and all Interested Parties,

This is in advance of Restem, LLC v. Jadi Cell, LLC, Case No. IPR2021-01535, U.S. Patent No. 9,803,176 United States Patent & Trademark Office, Patent Trial & Appeal Board Hearing: February 10, 2023, 1pm EST.

Our purpose in this filing is to share with the public certain information so that you may be aware of inconsistencies of testimony and facts in the matter referenced above. Keeping in mind that Dr. Ricordi and Restem have an ongoing working relationship that remains undisclosed to the court as of today. We draw your attention to pages 39 and 40 of Exhibit 99.4, where the Restem lawyer points out a significant issue and offer our concerns in Exhibit 99.1, 99.2, and 99.3. Neither UM or JadiCell LLC has responded to our request for documentation and clarification sent over 30 days ago. TSOI hopes and trusts that the attached exhibits make the facts and circumstances regarding this matter much clearer for all readers who wish to seek the truth.

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