Patrys Limited announced further pre-clinical data for its drug candidate PATDX1-NP. This candidate links PAT-DX1, Patrys’ humanized version of the 3E10 anti-DNA antibody, to nanoparticles (NPs) that can be loaded with chemotherapeutic (or other) drugs. As part of the tumor localization study recently completed at Yale University, Drs James Hansen and Jiangbing Zhou made the discovery that PAT-DX1-NPs appeared not only to localise to primary tumors, but also to axillary lymph node metastases. Axillary lymph nodes are the most common sites to which breast cancer initially metastasizes. In the Yale study, mice with breast cancer tumors were treated with free NPs or PAT-DX1-NPs, with both sets of nanocarriers loaded with a staining reagent to allow them to be directly tracked in the mice by an imaging system. The PAT-DX1-NPs showed improved targeting of the primary tumors, which is consistent with previous studies with murine 3E10 and PAT-DX1 in breast and glioblastoma tumor models. Remarkably, the PAT-DX1-NPs also appeared to target nearby axillary lymph node metastases. As PAT-DX1 targets the cloud of extracellular DNA released by dying cancer cells it is not surprising that PAT-DX1-NPs have a potential to target not only primary tumors but cancerous cells elsewhere in the body including lymph nodes and distant metastases, but this is the first direct evidence of this effect in an animal study.