On December 30, 2020, Lantern Pharma Inc. and AF Chemicals, LLC ("AF Chemicals") entered into a Second Addendum to Technology License Agreement (the "Second Addendum"). The Second Addendum provides for further additions and amendments to the Technology License Agreement and Addendum the company has previously entered into with AF Chemicals for the exclusive license of global patent rights from AF Chemicals for the treatment of cancer in humans for the company's product candidates LP-100 (Irofulven) and LP-184. The Second Addendum provides that, from December 30, 2020 until January 15, 2025, the company will have no obligation to pay annual licensing fees, development diligence extension payments, or patent maintenance fee payments to AF Chemicals under the AFC License Agreement. The Second Addendum also provides for the company to make specified payments to AF Chemicals within 10 days after signing and by March 31, 2021. As part of the Second Addendum, the company has agreed to apply for specified orphan drug designations for LP-184 in the US and EU. The Second Addendum also amends and clarifies other provisions of the Technology License Agreement, and provides the company with the ability to recover a portion of initial payments made under the Second Addendum from sublicense fees or royalty payments that may be made to AF Chemicals by the company or third parties prior to January 15, 2025. The AFC License Agreement, as amended by the Second Addendum, provides that the term of the agreement shall continue until the later of the expiration of the last patent licensed to the company has under the agreement, and the last to expire orphan drug designation, if any, relating to the company product candidate LP-184 or other specified licensed technology under the agreement.