Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On January 3, 2023, Karuna Therapeutics, Inc. (the "Company") and Charmaine Lykins mutually agreed that Ms. Lykins will depart from the Company effective January 5, 2023. The Company expects to enter into a separation agreement with Ms. Lykins that provides for a general release and waiver of claims against the Company, and pursuant to which Ms. Lykins will receive the severance benefits that are provided for under Section 5(b) of her Employment Agreement effective November 29, 2021 as a result of her departure.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)

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