On May 21, 2018, Charles Darder informed Kadmon Holdings, Inc. that he will resign from the Company as Principal Accounting Officer, Controller, to pursue other opportunities. Mr. Darder’s resignation is effective on June 1, 2018. Upon the effectiveness of Mr. Darder’s resignation, Konstantin Poukalov, Chief Financial Officer, will serve as the Company’s principal accounting officer in addition to continuing as principal financial officer.