On February 15, 2023, Chidozie Ugwumba, a Class II director of Clene Inc. (the “Company”), informed the Board of Directors of the Company (the “Board”) of his decision to resign from the Board and all committees thereof, effective immediately. Mr. Ugwumba was a member of the Audit Committee. Mr. Ugwumba resigned in order to focus his limited time on other professional opportunities, and not as a result of a disagreement on any matter relating to the Company's operations, policies, or practices, including any accounting or financial policies or practices.

On February 15, 2023, in connection with Mr. Ugwumba's resignation, the Board appointed John H. Stevens, M.D., a current director of the Company, to the Audit Committee. The Audit Committee continues to be comprised of three independent directors – Alison H. Mosca, Shalom Jacobovitz, and Dr. Stevens.