Aptamer Group plc announced the recent signing of two new fee-for-service contracts initially worth over £500,000, subject to the successful progression of Optimer development, with the potential for downstream milestone and royalty/licensing payments. These latest contracts are in addition to £1.0 million of recognised revenue in H1, as well as the additional £1.0 million in signed orders, announced in Aptamer's recent trading update. The first contract is with BaseCure Therapeutics, a pre-clinical stage biotech company dedicated to the discovery and development of innovative siRNA-based medicines.

Aptamer is working with BaseCure Therapeutics to identify cell targeting Optimer binders that might be developed as potential delivery vehicles for siRNA uptake into target cells and tissues. The ability to achieve Optimer-directed targeted delivery would offer exciting new therapeutic opportunities of siRNA-mediated gene knockdown in these target cells and tissues. The second contract is with a developer of custom enzymes based in Asia.

Aptamer will develop Optimer binders for incorporation into a biosensor to allow convenient monitoring of the ingredients in the company's manufacturing processes. As these ingredients are typically small molecule targets, antibodies often struggle to develop the required levels of selectivity to these targets.