(Alliance News) - The following stocks are the leading risers and fallers on AIM in London on Wednesday.

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AIM - WINNERS

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Aptamer Group PLC, up 23% at 0.77 pence, 12-month range 0.45p-8.50p. Aptamer says it reached an agreement with AstraZeneca PLC. The York, England-based biotechnology firm says the agreement aims to explore Optimer vehicles for targeted delivery of small interfering RNA, known as siRNA. Cambridge-based pharmaceutical company AstraZeneca will provide an siRNA to be trialled with Aptamer's Optimer-based delivery vehicle for fibrotic liver cells, Aptamer says. Aptamer Chief Technical Officer Arron Tolley says: "Partnerships such as this will enable Aptamer Group to make rapid progress in this area, which is a key focus for Optimer technology. Targeted delivery to specific cell types remains a critical unmet need in many applications within the tissue targeting space and, as such, has been part of our strategic focus to support the development of binders with the potential for long-term, high value."

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ECR Minerals PLC, up 19% at 0.34p, 12-month range 0.19p-0.55p. The gold exploration company announces the latest results for additional testing for the critical mineral Antimony from diamond core previously drilled at Bailieston, Central Victoria, Australia. "We've identified a highly promising opportunity at Bailieston that warrants further follow-up. The discovery of 32% Antimony over an intersection of 0.3m, coupled with multiple other highly anomalous results, marks a significant breakthrough and validates our decision to re- submit these samples for further analysis," said Chief Operating Officer Mike Whitlow. "The finding is truly remarkable, especially considering the current surge of interest and demand for the critical mineral."

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AIM - LOSERS

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Physiomics PLC, down 43% at 0.68p, 12-month range 0.64p-3.19p. The data science company, focused on new therapeutics and personalised medicine solutions, completes GBP381,417 placing, through issue of 63.6 million shares priced at GBP0.006 each. Also announces plans to raise GBP25,000 through a retail offer. It says it will issue a further 4.2 million shares at the same price.

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By Sophie Rose, Alliance News senior reporter

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