Amryt Pharma : Corporate Overview January 2021

CORPORATE OVERVIEW

January 2021

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The Amryt logo, Myalept®, Myalepta®, Juxtapid®, Lojuxta®, Filsuvez® and other trademarks or service marks of Amryt appearing in this presentation are the property of Amryt. This presentation includes trademarks, tradenames and service marks, certain of which belong to us and others that are the property of other organizations. Solely for convenience, trademarks, tradenames and service marks referred to in this presentation appear without the ®, TM and SM symbols, but the absence of those symbols is not intended to indicate, in any way, that we will not assert our rights or that the applicable owner will not assert its rights to these trademarks, tradenames and service marks to the fullest extent under applicable law. We do not intend our use or display of other parties' trademarks, trade names or service marks to imply, and such use or display should not be construed to imply, a relationship with, or endorsement or sponsorship of us by, these other parties. Filsuvez® (Oleogel-S10/birch triterpenes/formerly known as AP101) is currently an investigational product and has not received regulatory approval by the FDA or EMA. Elements of this presentation only apply in the event that Filsuvez® is approved by the appropriate regulatory authorities.

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AMRYT - CORPORATE OVERVIEW

Global, commercial-stage biopharmaceutical company dedicated to acquiring, developing and commercializing novel therapeutics for patients with serious and life-threatening rare diseases.

Corporate Overview

EBITDA profitable and growing commercial business with two commercial products and a significant development pipeline

Founded in 2015

Global HQ in Dublin, Ireland; U.S. HQ in Boston, MA

Positive results from pivotal Oleogel-S10 Phase 3 EASE trial in EB

Financials

Nasdaq : AMYT (trades ADSs, 5 Ordinary Shares per ADS)

LSE/AIM : AMYT (trades Ordinary Shares)

Revenues: $140.1M 9 months ended Sep 2020; Guiding $180-182M FY2020 ($154.1M FY2019*)

EBITDA: $25.0M 9 months ended Sep 2020**

$21.1M operating cashflows in 9 months ended Sep 2020 $75.4M cash balance as at 30 Sep 2020

$40M new equity raise Dec 2020

• Unaudited combined revenues for 2019 represent the combined unaudited pro forma revenues of the Company assuming the acquisition by Amryt of Aegerion happened on 1 January 2019. These amounts (i) exclude revenues

4 from sales to end-users in Japan, due to the out-licencing of Juxtapid® to Recordati, which occurred in February 2019, (ii) exclude up-front payments from Recordati in 2019, and (iii) include a 22.5% royalty on Japanese sales of Juxtapid® from 1 January 2019, as if the Recordati agreement were in place from that date. ** See Appendix: non-GAAP/IFRS reconciliation