Certain Options of Akcea Therapeutics, Inc. are subject to a Lock-Up Agreement Ending on 10-JAN-2018. These Options will be under lockup for 181 days starting from 13-JUL-2017 to 10-JAN-2018. Details: Ionis Pharmaceuticals, Inc, Novartis Pharma AG, officers, directors and substantially all of option holders have agreed that for a period of 180 days from the date of the prospectus that they will not dispose of or hedge any shares or any securities convertible into or exchangeable for common stock without the prior written consent of the Cowen and Company, LLC.