Valuation: Septerna, Inc.

Market Cap 2.08B 1.79B 1.69B 1.53B 2.88B 199B 2.93B 19.75B 7.72B 99.46B 7.8B 7.63B 331B P/E 2026 *
-33.8x
P/E 2027 * -19.9x
Enterprise Value 1.63B 1.41B 1.32B 1.2B 2.26B 156B 2.3B 15.51B 6.07B 78.11B 6.12B 5.99B 260B EV / Sales 2026 *
16.7x
EV / Sales 2027 * 20.6x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
1 day-1.42%
1 week+14.60%
Current month+29.17%
1 month+30.61%
3 months+65.12%
6 months+61.82%
Current year+59.61%
1 week 38.05
Extreme 38.0501
51.1
1 month 30.55
Extreme 30.55
51.1
Current year 22.78
Extreme 22.78
51.1
1 year 10.74
Extreme 10.74
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 31/10/2021
Director of Finance/CFO 55 05/01/2025
President 58 31/07/2025
Director TitleAgeSince
Director/Board Member 60 31/10/2021
Chairman 50 31/10/2021
Director/Board Member 41 31/10/2021
Date Insider Type Main position Quantity % Market Cap.
11/08/26 Fiscal year

Chairperson

75,000 0.1664%
03/08/26 Fiscal year

Executive/Senior Manager

10,002 0.0222%
15/07/26 Fiscal year

Chairperson

12,000 0.0266%
Change 5-day change 1-year change 3-year change Capi.($)
-1.42%+14.60%+279.69% - 2.08B
-1.78%-1.68%+1.48%+15.31% 48.42B
+0.85%-0.70%+460.88%+563.55% 43.66B
-2.40%-0.23%+8.13%+71.41% 39.51B
-2.01%-0.85%+23.85%+8.73% 38.95B
-0.50%+0.85%+20.60%+49.65% 32.61B
+0.38%-3.23% - - 16.32B
-0.59%-2.06%+26.35%+118.09% 16.15B
+0.49%+0.92%+4.11%+23.67% 14.16B
-0.43%+4.70%+78.74%+33.31% 13.37B
Average -0.74%+1.90%+100.42%+110.46% 26.52B
Weighted average by Cap. -0.92%+0.70%+97.36%+132.95%

Financials

2026 *2027 *
Net sales 97.57M 84.27M 79.19M 72.02M 135M 9.33B 138M 928M 363M 4.67B 366M 358M 15.53B 75.03M 64.81M 60.9M 55.38M 104M 7.17B 106M 714M 279M 3.59B 282M 276M 11.94B
Net income -59.68M -51.54M -48.43M -44.05M -82.81M -5.71B -84.18M -568M -222M -2.86B -224M -219M -9.5B -113M -97.38M -91.51M -83.22M -156M -10.78B -159M -1.07B -419M -5.4B -423M -414M -17.94B
Net Debt -446M -385M -362M -329M -619M -42.64B -629M -4.24B -1.66B -21.35B -1.67B -1.64B -70.95B -528M -456M -429M -390M -733M -50.54B -746M -5.03B -1.97B -25.31B -1.98B -1.94B -84.1B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
14/08/26 US$44.50 -1.42% 630,368
13/08/26 US$45.14 -6.33% 877,878
12/08/26 US$48.19 +0.90% 1,261,317
11/08/26 US$47.76 +22.93% 1,159,567
10/08/26 US$38.85 +0.05% 275,481
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
44.50USD
Average target price
53.11USD
Spread / Average Target
+19.35%

Quarterly revenue - Rate of surprise

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