Valuation: Septerna, Inc.

Market Cap 1.57B 1.37B 1.27B 1.18B 2.23B 148B 2.28B 15.24B 5.88B 73.06B 5.88B 5.75B 254B P/E 2026 *
-20.1x
P/E 2027 * -14.4x
Enterprise Value 1.22B 1.07B 984M 919M 1.73B 115B 1.77B 11.84B 4.57B 56.79B 4.57B 4.47B 197B EV / Sales 2026 *
15.8x
EV / Sales 2027 * 16.1x
Free-Float
97.17%
Yield 2026 *
-
Yield 2027 * -
1 day-6.94%
1 week-0.29%
Current month+15.07%
1 month+15.07%
3 months+45.58%
6 months+22.45%
Current year+24.64%
1 week 32
Extreme 32
37.99
1 month 27.08
Extreme 27.075
37.99
Current year 22.78
Extreme 22.78
37.99
1 year 10.3
Extreme 10.3
37.99
3 years 4.17
Extreme 4.17
37.99
5 years 4.17
Extreme 4.17
37.99
10 years 4.17
Extreme 4.17
37.99
Manager TitleAgeSince
Chief Executive Officer 60 31/10/2021
Director of Finance/CFO 55 05/01/2025
President 58 31/07/2025
Director TitleAgeSince
Director/Board Member 60 31/10/2021
Chairman 50 31/10/2021
Director/Board Member 41 31/10/2021
Date Insider Type Main position Quantity % Market Cap.
06-21Fiscal year

Executive/Senior Manager

45,000 0.0998%
06-11Fiscal year

Head of Human Resources

18,750 0.0416%
05-31Fiscal year

Head of Human Resources

17,805 0.0395%
Change 5-day change 1-year change 3-year change Capi.($)
-6.94%-0.29%+230.64% - 1.57B
+0.94%+7.83%-4.77%+3.17% 46.62B
+5.79%+16.17%+421.86%+634.63% 40.95B
+1.12%+15.18%+22.74%-12.71% 32.26B
+3.61%+6.69%+20.23%+62.38% 32.24B
+8.02%+6.35%+17.67%+34.73% 25.53B
+1.13%+15.66% - - 16.38B
+1.45%+17.35%+72.11%+127.60% 15.27B
-1.13%+7.40%+12.03%+20.67% 13.61B
-0.60%+6.32%+102.74%+96.28% 13.34B
Average +1.34%+10.40%+99.47%+120.84% 23.78B
Weighted average by Cap. +2.71%+11.51%+98.86%+146.20%

Financials

2026 *2027 *
Net sales 76.94M 67.37M 62.2M 58.08M 109M 7.27B 112M 748M 289M 3.59B 289M 283M 12.46B 65.86M 57.67M 53.24M 49.72M 93.59M 6.23B 95.72M 641M 247M 3.07B 247M 242M 10.67B
Net income -68.86M -60.29M -55.66M -51.97M -97.84M -6.51B -100M -670M -259M -3.21B -259M -253M -11.15B -122M -107M -98.35M -91.84M -173M -11.5B -177M -1.18B -457M -5.68B -457M -447M -19.7B
Net Debt -349M -305M -282M -263M -496M -32.99B -507M -3.39B -1.31B -16.27B -1.31B -1.28B -56.5B -508M -445M -411M -384M -722M -48.07B -739M -4.95B -1.91B -23.72B -1.91B -1.87B -82.34B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
130
Date Price Change Volume
29/06/26 US$34.75 -6.94% 1,432,558
26/06/26 US$37.34 +8.11% 1,480,133
25/06/26 US$34.54 -4.19% 324,557
24/06/26 US$36.05 -1.42% 357,572
23/06/26 US$36.57 +4.94% 312,456
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
34.75USD
Average target price
44.89USD
Spread / Average Target
+29.18%

Quarterly revenue - Rate of surprise

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