Valuation: Septerna, Inc.

Market Cap 1.56B 1.37B 1.26B 1.17B 2.22B 148B 2.26B 15.16B 5.88B 72.8B 5.86B 5.73B 253B P/E 2026 *
-20x
P/E 2027 * -14.2x
Enterprise Value 1.21B 1.06B 979M 912M 1.72B 115B 1.76B 11.77B 4.56B 56.52B 4.55B 4.45B 197B EV / Sales 2026 *
15.7x
EV / Sales 2027 * 16x
Free-Float
97.17%
Yield 2026 *
-
Yield 2027 * -
1 day+3.34%
1 week-3.99%
Current month+3.34%
1 month+15.44%
3 months+42.02%
6 months+24.14%
Current year+24.14%
1 week 32
Extreme 32
37.48
1 month 29.57
Extreme 29.57
37.99
Current year 22.78
Extreme 22.78
37.99
1 year 10.62
Extreme 10.6161
37.99
3 years 4.17
Extreme 4.17
37.99
5 years 4.17
Extreme 4.17
37.99
10 years 4.17
Extreme 4.17
37.99
Manager TitleAgeSince
Chief Executive Officer 60 31/10/2021
Director of Finance/CFO 55 05/01/2025
President 58 31/07/2025
Director TitleAgeSince
Director/Board Member 60 31/10/2021
Chairman 50 31/10/2021
Director/Board Member 41 31/10/2021
Date Insider Type Main position Quantity % Market Cap.
06-21Fiscal year

Executive/Senior Manager

45,000 0.0998%
06-11Fiscal year

Head of Human Resources

18,750 0.0416%
05-31Fiscal year

Head of Human Resources

17,805 0.0395%
Change 5-day change 1-year change 3-year change Capi.($)
+3.34%-3.99%+226.51% - 1.51B
+3.08%+6.47%-0.25%+5.47% 47.18B
+0.12%+10.45%+408.29%+600.97% 39.82B
+5.17%+9.47%+24.96%-9.60% 32.25B
+2.02%+4.91%+18.59%+63.06% 31.68B
+0.69%+1.04%+14.23%+30.86% 24.59B
+0.40%+12.51% - - 16.57B
+2.64%+6.00%+69.30%+126.33% 15.12B
-0.15%+2.15%+12.64%+17.71% 13.69B
-0.13%+3.49%+98.27%+93.01% 13.1B
Average +1.72%+3.38%+96.95%+115.98% 23.55B
Weighted average by Cap. +1.89%+4.44%+95.18%+138.00%

Financials

2026 *2027 *
Net sales 76.94M 67.56M 62.18M 57.94M 109M 7.32B 111M 748M 290M 3.59B 289M 283M 12.5B 65.86M 57.83M 53.23M 49.6M 93.54M 6.26B 95.44M 640M 248M 3.07B 247M 242M 10.7B
Net income -68.86M -60.46M -55.65M -51.85M -97.79M -6.55B -99.78M -669M -259M -3.21B -259M -253M -11.18B -122M -108M -98.96M -92.21M -174M -11.64B -177M -1.19B -461M -5.71B -460M -450M -19.89B
Net Debt -349M -306M -282M -263M -496M -33.17B -506M -3.39B -1.31B -16.28B -1.31B -1.28B -56.67B -508M -446M -411M -383M -722M -48.34B -737M -4.94B -1.91B -23.73B -1.91B -1.87B -82.58B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
130
Date Price Change Volume
01/07/26 US$34.61 +3.34% 440,357
30/06/26 US$33.49 -3.63% 747,647
29/06/26 US$34.75 -6.94% 1,432,558
26/06/26 US$37.34 +8.11% 1,480,133
25/06/26 US$34.54 -4.19% 324,557
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
34.61USD
Average target price
45.00USD
Spread / Average Target
+30.02%

Quarterly revenue - Rate of surprise

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