Valuation: Septerna, Inc.

Market Cap 1.7B 1.51B 1.4B 1.27B 2.4B 161B 2.44B 16.8B 6.59B 84.03B 6.37B 6.23B 268B P/E 2026 *
-26.9x
P/E 2027 * -15.9x
Enterprise Value 1.32B 1.17B 1.08B 987M 1.86B 125B 1.89B 13.04B 5.11B 65.21B 4.94B 4.84B 208B EV / Sales 2026 *
13.7x
EV / Sales 2027 * 16.6x
Free-Float
99.2%
Yield 2026 *
-
Yield 2027 * -
1 day-2.94%
1 week-5.26%
Current month-7.10%
1 month-7.97%
3 months+8.83%
6 months+39.11%
Current year+30.38%
1 week 34.36
Extreme 34.36
38.51
1 month 34.36
Extreme 34.36
41.09
Current year 22.78
Extreme 22.78
51.1
1 year 17.55
Extreme 17.55
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 31/10/2021
President 58 31/07/2025
Director of Finance/CFO 55 05/01/2025
Director TitleAgeSince
Director/Board Member 60 31/10/2021
Chairman 50 31/10/2021
Director/Board Member 41 31/10/2021
Date Insider Type Main position Quantity % Market Cap. Importance
08/09/26 Free

Chief Technology Officer

275,000 0.5892%
01/09/26 Exercice

Executive/Senior Manager

9,999 0.0214%
12/08/26
RA Capital Management LP
SellCompany -1,493,000 3.3122%
Change 5-day change 1-year change 3-year change Capi.($)
-2.94%-5.26%+64.78% - 1.7B
-6.60%-8.56%+49.38%+63.51% 65B
+0.03%+5.56%+9.10%+69.05% 51.2B
-4.09%-0.11%+2.22%+53.15% 51.19B
-1.53%+2.70%+30.48%+34.12% 43.93B
-1.34%+4.12%+16.64%+115.13% 41.96B
-5.97%-6.22%+228.95%+454.22% 38.14B
+6.53%+8.02%+16.40%+53.41% 33.24B
-0.90%-10.49%+37.09%-3.70% 25.2B
-1.07%+2.33%+19.43%+9.98% 22.5B
Average -1.79%-0.84%+47.45%+94.32% 37.41B
Weighted average by Cap. -2.20%-0.52%+44.34%+96.53%

Financials

2026 *2027 *
Net sales 96.14M 85.46M 79.21M 72.06M 136M 9.12B 138M 952M 373M 4.76B 361M 353M 15.18B 73.64M 65.46M 60.67M 55.2M 104M 6.99B 106M 729M 286M 3.65B 276M 270M 11.63B
Net income -61.3M -54.49M -50.5M -45.95M -86.71M -5.82B -88.1M -607M -238M -3.04B -230M -225M -9.68B -115M -102M -94.81M -86.26M -163M -10.92B -165M -1.14B -447M -5.7B -432M -423M -18.17B
Net Debt -380M -338M -313M -285M -538M -36.06B -546M -3.76B -1.48B -18.82B -1.43B -1.4B -60B -476M -423M -392M -357M -674M -45.2B -684M -4.72B -1.85B -23.59B -1.79B -1.75B -75.2B
Projected Income Statement - Annual - Septerna, Inc.
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. It is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. The Company's Native Complex Platform is designed to enable it to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
16/10/26 US$36.35 -2.94% 234,140
15/10/26 US$37.45 +3.11% 271,437
14/10/26 US$36.32 -0.26% 369,978
13/10/26 US$36.42 -3.05% 491,852
12/10/26 US$37.56 -2.11% 207,564
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
MarketScreener Ratings - Septerna, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
36.35USD
Average target price
54.22USD
Spread / Average Target
+49.17%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Septerna, Inc.
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