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Valuation: Karyopharm Therapeutics Inc.

Capitalization 161M 139M 125M 120M 219M 14.78B 229M 1.48B 593M 7.09B 604M 591M 25.36B P/E ratio 2026 *
-1.73x
P/E ratio 2027 * -3x
Enterprise value 443M 382M 345M 331M 603M 40.7B 631M 4.07B 1.63B 19.52B 1.66B 1.63B 69.8B EV / Sales 2026 *
3.18x
EV / Sales 2027 * 0.79x
Free-Float
93.2%
Yield 2026 *
-
Yield 2027 * -
1 day-0.57%
1 week-6.80%
Current month-6.80%
1 month+40.10%
3 months+48.90%
6 months+40.32%
Current year+19.16%
1 week 8.57
Extreme 8.57
9.59
1 month 6.2
Extreme 6.2018
10.99
Current year 5.88
Extreme 5.875
10.99
1 year 3.51
Extreme 3.51
10.99
3 years 3.51
Extreme 3.51
73.05
5 years 3.51
Extreme 3.51
220.95
10 years 3.51
Extreme 3.51
444.15
Manager TitleAgeSince
Chief Executive Officer 58 02/05/2021
Director of Finance/CFO 55 02/01/2025
Chief Tech/Sci/R&D Officer - 31/03/2023
Director TitleAgeSince
Director/Board Member 62 31/12/2012
Director/Board Member 61 31/03/2013
Director/Board Member 78 02/10/2013
Change 5d. change 1-year change 3-years change Capi.($)
-0.57%-6.80%+27.29%-81.20% 161M
-0.66%-2.79%+7.40%+1.97% 77.98B
-2.68%-0.52%+33.16%+213.44% 55.42B
-0.18%+64.40%+64.40%+64.40% 51.24B
-3.00%-3.68%-44.45%-51.16% 49.37B
-1.71%-3.62%+22.94%-29.71% 27.13B
-2.43%-1.96%+47.49%-63.03% 20.74B
-1.43%-5.26%+35.53%+30.02% 19.09B
-4.20%-3.33%+104.74%+100.13% 18.48B
-1.21%-4.75%+27.92%+58.10% 14.15B
Average -1.80%-3.57%+32.64%+24.29% 33.38B
Weighted average by Cap. -1.72%-2.98%+24.39%+41.57%

Financials

2026 *2027 *
Net sales 139M 120M 108M 104M 189M 12.78B 198M 1.28B 513M 6.13B 522M 511M 21.92B 204M 176M 159M 152M 278M 18.74B 291M 1.88B 752M 8.99B 765M 749M 32.15B
Net income -128M -111M -99.76M -95.72M -175M -11.78B -183M -1.18B -472M -5.65B -481M -471M -20.2B -137M -118M -107M -102M -186M -12.58B -195M -1.26B -505M -6.03B -514M -503M -21.58B
Net Debt 282M 243M 219M 211M 384M 25.92B 402M 2.59B 1.04B 12.43B 1.06B 1.04B 44.45B -
Logo Karyopharm Therapeutics Inc.
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. It is developing and commercializing small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, mycosis fungoides (MF) and diffuse large B-cell lymphoma (DLBCL). The Company’s product candidate, eltanexor, oral SINE compound that, like selinexor, selectively blocks the nuclear export protein XPO1.
Employees
228
Date Price Change Volume
06/03/26 8.770 $ -0.57% 725,196
05/03/26 8.820 $ -3.61% 509,407
04/03/26 9.150 $ +0.22% 397,719
03/03/26 9.130 $ -4.80% 1,718,600
02/03/26 9.590 $ +1.91% 507,469
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
8.770USD
Average target price
15.33USD
Spread / Average Target
+74.84%

Quarterly revenue - Rate of surprise

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