Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.

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129

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Biotechnology & Medical Research

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Delayed Nasdaq Other stock markets 21:00:00 23/06/2026 BST			5-day change	1st Jan Change
40.50 ^USD	+0.80%		-.--%	+61.94%

06-24	Swiss Market Index Extends Rally; OC Oerlikon Shares Gain	MT
06-24	Eli Lilly Completes Acquisition of Centessa Pharmaceuticals	MT

Market Cap	6.27B 5.5B 5.12B 4.7B 8.83B 603B 8.96B 60.78B 23.75B 297B 23.52B 23.02B 1,026B	P/E 2024	-8.13x	P/E 2025	-17.2x
Enterprise Value	6.09B 5.35B 4.97B 4.56B 8.58B 587B 8.71B 59.07B 23.08B 288B 22.86B 22.37B 997B	EV / Sales 2024	-	EV / Sales 2025	231,810,355x
Free-Float	78.43%	Yield 2024 *	-	Yield 2025	-

06-24	Swiss Market Index Extends Rally; OC Oerlikon Shares Gain	MT
06-24	Eli Lilly Completes Acquisition of Centessa Pharmaceuticals	MT
06-23	Centessa Pharmaceuticals plc(NasdaqGM:CNTA) dropped from NASDAQ Composite Index	CI
06-23	Centessa Pharmaceuticals plc(NasdaqGS:CNTA) dropped from NASDAQ Biotechnology Index	CI
06-23	Eli Lilly and Company completed the acquisition of Centessa Pharmaceuticals plc from Medicxi Ventures (UK) LLP, Index Ventures SA, General Atlantic Service Company, L.P. and other shareholders.	CI
06-22	UK High Court Approves Lilly's $7.8 Billion Acquisition of Centessa	MT
06-22	Centessa Pharmaceuticals plc(NasdaqGS:CNTA) dropped from S&P Global BMI Index	CI
05-26	Eli Lilly to Acquire Three Vaccine Developers for Up to $3.83 Billion	MT
05-20	Eli Lilly Buys Engage Biologics for Up to $202 Million	DJ
05-06	Eli Lilly Plans to Sell About $8 Billion of Bonds to Fund Acquisitions	MT
05-06	Eli Lilly Plans to Sell About $8 Billion of Bonds to Fund Acquisitions	MT
05-05	Centessa Pharmaceuticals plc Reports Earnings Results for the First Quarter Ended March 31, 2026	CI
04-27	Eli Lilly to Buy Ajax Therapeutics for Up to $2.3 Billion -- Update	DJ

04-20	Wells Fargo Downgrades Centessa Pharmaceuticals ADR to Equal Weight From Overweight, Adjusts Price Target to $42 From $35	MT
04-01	B. Riley Downgrades Centessa Pharmaceuticals to Neutral From Buy, Lifts Price Target to $45 From $42	MT
04-01	Leerink Partners Downgrades Centessa Pharmaceuticals to Market Perform From Outperform, $36 Price Target	MT
12-10	Centessa Set to Redefine Narcolepsy Treatment, Oppenheimer Says	MT
12-10	Oppenheimer Adjusts Centessa Pharmaceuticals PT to $62 From $40, Maintains Outperform Rating	MT

Centessa Pharmaceuticals plc Share Price

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CNTA

US1523091007

Biotechnology & Medical Research

Valuation: Centessa Pharmaceuticals plc

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06-22	Acquisition of Centessa by Lilly Approved by the High Court of Justice of England and Wales	GL
05-11	Centessa Pharmaceuticals Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Centessa Pharmaceuticals plc - CNTA	BU
04-01	Centessa Pharmaceuticals Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Centessa Pharmaceuticals plc - CNTA	BU
03-31	Are APLS, CNTA, BIRD Obtaining Fair Deals for their Shareholders?	PR
03-31	CNTA Stock Alert: Halper Sadeh LLC is Investigating Whether Centessa Pharmaceuticals plc is Obtaining a Fair Price for its Shareholders	BU

04-01	Morning Meeting: Ahora el petróleo es vuestro problema
03-31	Wall Street termine en hausse, rassurée par les propos de Washington et Téhéran
03-31	Trump maintient Téhéran sous pression et griffe ses alliés... Wall Street apprécie
03-31	Wall Street ouvre en nette hausse, veut croire à une désescalade au Moyen-Orient
03-31	Hausse attendue des indices américains avant le rapport JOLTS, le conflit au Moyen-Orient s'enlise

Current year	21.5	40.56
1 year	15.01	40.56
3 years	5.15	40.56
5 years	2.88	40.56
10 years	2.88	40.56

Manager	Title	Age	Since
Charlene Stoudt CTO	Chief Tech/Sci/R&D Officer	-	30/09/2024
Tia Bush CTO	Chief Tech/Sci/R&D Officer	55	28/02/2023
David Chao ADM	Chief Administrative Officer	58	31/03/2021

Director	Title	Age	Since
Christopher Stokes BRD	Director/Board Member	-	23/06/2026
Kristina Wright BRD	Director/Board Member	-	23/06/2026

Date	Insider	Type	Main position	Quantity	% Market Cap.
24/06/26	Medicxi Ventures (Jersey) Ltd.	Sell	Company	-9,961,789	6.4382%
24/06/26	John Crowley	Issuer sale	Chief Financial Officer	-1,076,000	0.6954%
24/06/26	Raphael Deferiere	Issuer sale	Controller/Auditor	-218,000	0.1409%

Add to a list 0 selected To use this feature you must be a member Log in Sign up	Change	5-day change	1-year change	3-year change	Capi.($)
CENTESSA PHARMACEUTICALS PLC	+0.80%	-.--%	+162.82%	+451.02%	6.27B
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IQVIA HOLDINGS INC.	+1.24%	+3.17%	+6.37%	-6.32%	34.72B
CELLTRION, INC.	+0.62%	+1.65%	+5.41%	+43.89%	27.89B
MEDPACE HOLDINGS, INC.	-1.72%	+12.06%	+30.58%	+137.71%	16.79B
ASCENDIS PHARMA A/S	+0.63%	+1.55%	-	-	16.74B
EUROFINS SCIENTIFIC SE	+0.78%	-5.88%	+2.29%	+7.76%	13.12B
ICON PUBLIC LIMITED COMPANY	+0.95%	-0.08%	-12.45%	-31.28%	12.7B
Average	+0.40%	+1.06%	+67.70%	+146.33%	25.15B
Weighted average by Cap.	+0.43%	+1.08%	+78.35%	+146.66%

	2024	2025
Net sales	-	15 13.17 12.25 11.24 21.12 1.44K 21.45 145.49 56.84 710.17 56.31 55.1 2.46K
Net income	-236M -207M -193M -177M -332M -22.7B -337M -2.29B -893M -11.16B -885M -866M -38.59B	-198M -173M -161M -148M -278M -19.02B -282M -1.92B -749M -9.35B -742M -726M -32.34B
Net Debt	-364M -320M -298M -273M -513M -35.09B -521M -3.53B -1.38B -17.25B -1.37B -1.34B -59.64B	-176M -155M -144M -132M -248M -16.97B -252M -1.71B -668M -8.34B -661M -647M -28.84B

1 day	+0.80%
3 months	+2.61%
6 months	+57.40%
Current year	+61.94%