Valuation: Centessa Pharmaceuticals plc

Market Cap 6.27B 5.5B 5.09B 4.68B 8.86B 600B 9.03B 60.67B 23.8B 295B 23.53B 23.02B 1,017B P/E 2024
-8.13x
P/E 2025 -17.2x
Enterprise Value 6.09B 5.34B 4.95B 4.55B 8.61B 583B 8.78B 58.97B 23.13B 286B 22.87B 22.37B 989B EV / Sales 2024
-
EV / Sales 2025 231,810,355x
Free-Float
78.43%
Yield 2024 *
-
Yield 2025 -
1 day+0.80%
1 month+1.96%
3 months+2.35%
6 months+82.27%
Current year+61.94%
1 month 39.66
Extreme 39.66
40.56
Current year 21.5
Extreme 21.5
40.56
1 year 14.75
Extreme 14.7474
40.56
3 years 5.15
Extreme 5.15
40.56
5 years 2.88
Extreme 2.885
40.56
10 years 2.88
Extreme 2.885
40.56
Manager TitleAgeSince
Chief Tech/Sci/R&D Officer - 30/09/2024
Chief Tech/Sci/R&D Officer 55 28/02/2023
Chief Administrative Officer 58 31/03/2021
Director TitleAgeSince
Director/Board Member - 23/06/2026
Director/Board Member - 23/06/2026
Date Insider Type Main position Quantity % Market Cap.
06-23Issuer sale

Controller/Auditor

-218,000 0.1409%
06-23Issuer sale

Chief Technology Officer

-620,000 0.4007%
06-23Issuer sale

Director

-392,474 0.2537%
Change 5-day change 1-year change 3-year change Capi.($)
+0.80%-.--%+180.67%+441.44% 6.27B
-0.90%+1.92%+3.68%+7.53% 50.61B
+1.27%-2.79%+382.53%+594.47% 39.11B
-1.07%-0.70%+29.13%-6.48% 34.64B
+0.21%-2.00%+20.08%+54.22% 33.79B
-0.06%-0.45%+2.94%+28.70% 26.89B
+0.41%-0.94% - - 16.47B
+0.02%-2.86%+65.64%+118.19% 15.14B
-0.23%+0.61%+15.26%+17.53% 13.85B
+0.15%-2.02%+10.56%-32.87% 12.72B
Average +0.09%-1.15%+78.94%+135.86% 24.95B
Weighted average by Cap. -0.02%-1.01%+83.19%+130.42%

Financials

2024 2025
Net sales - 15 13.16 12.19 11.21 21.21 1.44K 21.62 145.23 56.96 705.03 56.33 55.1 2.43K
Net income -236M -207M -192M -176M -333M -22.56B -340M -2.28B -895M -11.08B -885M -866M -38.27B -198M -173M -160M -148M -279M -18.91B -285M -1.91B -750M -9.28B -742M -726M -32.06B
Net Debt -364M -320M -296M -272M -515M -34.87B -525M -3.53B -1.38B -17.13B -1.37B -1.34B -59.14B -176M -155M -143M -132M -249M -16.86B -254M -1.71B -669M -8.28B -662M -647M -28.6B
Logo Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Employees
129
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