Jake Orville

PrognostiX, Inc. discovers and develops biomarker technologies. The firm also offers cardiovascular and inflammatory biomarkers. The company was founded in 2004 and is headquartered in Cleveland, OH.

Cleveland HeartLab, Inc. operates as a holding and clinical reference laboratory company. It focuses on novel molecular biomarker technologies and the creation of proprietary diagnostic tests. The company was founded by Jake Orville and Marc S. Penn in 2009 and is headquartered in Cleveland, OH.

Stealth Therapeutics, Inc. designs and develops a portfolio of venous access devices. It offers Invisiport, a micro-invasive implantable arm port that requires smaller incision and less anesthesia during insertion. The firm’s Invisiport solution is indicated for any patient requiring repeated access of the vascular system for delivery of medications, nutritional supplementation, fluids, blood, blood products, or the sampling of blood, or for power injection of contrast media when used with a power-injectible Huber needle or infusion set. The company was founded by Glenn Bradley in January 2006 and is headquartered in Madison, WI.

NextGen Sciences Ltd. provides technologies and reagents for molecular biology and protein research. Its advanced products automate and simplify complex research techniques, saving time and resources, improving results, and accelerating discovery. The company was founded on January 28, 2000 by Kevin Auton and David Wigley and is headquartered in Huntingdon, the United Kingdom.

Third Wave Technologies, Inc. developed DNA and RNA detection technology. It provided molecular solutions for clinical, research, and agricultural customers. The company was founded in February 1993 and was headquartered in Madison, WI.

Smiths Medical manufactures and supplies medical devices and equipment. It offers medical devices for the hospital, emergency, home, and specialist environments. The firm's products are used in intensive care, surgery, post-operative care during recovery, and in a series of high-end home infusion therapies. The company was founded by S. A. Leader in 1940 and is located in London, UK

Tolera Therapeutics, Inc. develops novel therapies and technologies for immune modulation. Its products include anti-aßTCR antibody an immune induction therapy in solid organ transplantation and graft versus host disease. The company was founded by Jake Orville, Maria Siemionow, James J. Herrmann and John J. Puisis in 2007 and is headquartered in Ann Arbor, MI.