Quoin Pharmaceuticals Ltd. announced the planned initiation of an investigator-led clinical study in New Zealand to evaluate the safety and efficacy of QRX003 in a pediatric patient with Peeling Skin Syndrome (PSS). QRX003 is Quoin?s most advanced pipeline product and is currently being evaluated in two late stage clinical trials in the United States as a potential treatment for Netherton Syndrome (NS). Both studies are being conducted under an open Investigational New Drug (IND) application with the Food and Drug Administration (FDA).
QRX003 is a unique ?whole body, whole life? topical lotion that targets the vicious circle of skin inflammation and barrier disruption. QRX003 is a unique ?whole body, whole life?
topical lotion that targets the vicious circle of skin inflammation and barrier disruption. Generalized inflammatory peeling skin syndrome (PSS) is a rare autosomal recessive genodermatosis caused by loss-of-function disease-causing variants of the corneodesmosin gene (CDSN), resulting in excessive shedding of the superficial layers of the epidermis. Patients generally suffer from a variety of conditions including severe pain and chronic pruritis (itch).
There is currently no approved treatment for PSS, and patients manage symptoms using over-the-counter emollients. QRX003 is a topical lotion, formulated with a proprietary delivery technology, and contains a broad- spectrum serine protease inhibitor, whose mechanism of action is intended to perform the function of a specific protein, called LEKTI. The absence of LEKTI in Netherton patients leads to excessive skin shedding resulting in a highly porous and compromised skin barrier.
QRX003 is designed to lead to a more normalized skin shedding process and the formation of a stronger and more effective skin barrier.
