Item 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

On February 25, 2021, Emmett Cunningham, M.D., Ph.D. resigned from the Board of Directors (the "Board") of Annexon, Inc. (the "Company"). Dr. Cunningham's resignation was due to his professional responsibilities to Blackstone Life Sciences and not a result of any disagreement with the Company or any matter relating to the Company's operations, policies or practices. In addition, in connection with Dr. Cunningham's resignation, director William H. Carson, M.D. was appointed to the Compensation Committee of the Board.

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