PharmaJet® announced that its partner Scancell has reported updated Phase 2 clinical data from the SCOPE study in unresectable advanced melanoma. In this study, Scancell's iSCIB1+ immunotherapy was delivered intramuscularly using Stratis, PharmaJet's Needle-free Injection System. Data was presented at the ESMO Immuno-Oncology Congress 2025 on December 11, 2025.
Advanced melanoma continues to represent a significant unmet medical need, with five-year survival rates of less than 23% for Stage IV patients, and an estimated 58,000 deaths annually. While immune checkpoint inhibitors have improved outcomes for many patients, approximately half either fail to respond or experience non-durable benefits, underscoring the need for novel therapeutics that extend and deepen clinical responses. Updated Phase 2 data of Scancell's iSCib1+ DNA immunotherapy delivered with PharmaJet's Stratis demonstrated a Progression-Free Survival (PFS) rate of 74% at 16 months, compared to 50% PFS at 11.5 months for standard-of-care checkpoint inhibitor therapy alone.
Based on these results, Scancell has indicated plans to initiate a registrational Phase 3 study in the second half of 2026 with its immunotherapy delivered with Stratis, PharmaJet's need. Subject to regulatory outcomes and achievement of clinical endpoints, Scancell has outlined plans to advance iSCIB1+ towards potential commercialization by 2029.
