Oxford Nanopore Technologies : Proxy Form for 2026 AGM

NOTICE OF AVAILABILITY - Important, please read carefully

The Oxford Nanopore Technologies plc 2026 Annual General Meeting ('AGM') is being held on Thursday 4 June 2026 at Oxford Nanopore Technologies plc, Gosling Building, Edmund Halley Road, Oxford Science Park, Oxford OX4 4DQ at 10.30 a.m. The 2025 Annual Report and Accounts, and a letter from the Chair including the Notice of AGM are now available to view online at https://www.nanoporetech.com/about/investors. There are

no particular software requirements to view documents on the website.

Details of the results of the voting at the AGM will be announced through the London Stock Exchange information service and will appear on https://www.nanoporetech.com/about/ investors/regulatory-news

If you have any queries, please contact our Registrar, Equiniti, on

[phone].

Lines are open from 8.30 a.m. to 5.30 p.m. Monday to Friday, excluding bank holidays in England and Wales.

Oxford Nanopore Technologies plc (the 'Company') 2026 Annual General Meeting

If you wish to attend this meeting in your capacity as a holder of ordinary shares, please sign this card and on arrival hand it to the Company's registrars. This will facilitate entry to the meeting.

Name of person attending Shareholder Reference Number Form of Proxy Oxford Nanopore Technologies plc - Annual General Meeting

Oxford Nanopore Technologies plc 2026 Annual General Meeting ('AGM') to be held on Thursday 4 June 2026 at Oxford Nanopore Technologies plc, Gosling Building, Edmund Halley Road, Oxford Science Park, Oxford OX4 4DQ at 10.30 a.m. or any adjournment thereof.

Shareholder Reference Number

Please read the notes (including the notes contained in the Notice of AGM) carefully.

I/We, being (a) holder(s) of ordinary shares of £0.0001 each in the capital of the Company HEREBY APPOINT the Chair of the Meeting or

Number of shares in relation to which the proxy may act

Against

Withheld

to be my/our proxy to vote for me/us on my/our behalf at the above-mentioned AGM of the Company and at any adjournment thereof, to attend, speak and vote on my/our behalf. We direct that my/our votes be cast on the Resolutions set out in the Notice of AGM convening the meeting as indicated by an 'X' in the appropriate box below and otherwise as my/our proxy shall think fit. Please indicate 'X' here if this is one of multiple proxies.

For

1. To receive and consider the Directors' report, the Audited Statement of Accounts and Auditor's Report of the Company for the financial year ended 31 December 2025 (the "Annual Report and Accounts")

2. To receive and approve the Directors' Remuneration Report for the year ended 31 December 2025, which is contained within the Annual Report and Accounts.

3. To elect Francis Van Parys as a director of the Company.

4. To re-elect Dr Sarah Fortune as a director of the Company.

5. To re-elect Adrian Hennah as a director of the Company.

6. To re-elect Nicholas Keher as a director of the Company.

7. To re-elect Dr Daniel Mahony as a director of the Company.

8. To re-elect John O'Higgins as a director of the Company

9. To re-elect Dr Heather Preston as a director of the Company

10. To re-elect Katherine (Kate) Priestman as a director of the Company

11. To re-elect Duncan Tatton-Brown as a director of the Company.

12. To appoint Deloitte LLP as auditors of the Company to hold office from the conclusion of the AGM until the conclusion of the Company's 2027 AGM at which accounts are laid before shareholders in accordance with the Companies Act 2006 (the "Act")

    For Against

    Withheld

13. That the Company's Audit & Risk Committee be authorised to fix the remuneration of Deloitte LLP as auditors of the Company

14. To authorise the board of directors to allot shares

15. To disapply pre-emption rights subject to approved limits*

16. To further disapply pre-emption rights subject to approved limits*

17. To authorise the Company to make market purchases*

18. To authorise the Company to hold any general meeting (other than an Annual General Meeting) on not less than 14 clear days notice*

19. To authorise UK political expenditure not exceeding £100,000

* Special resolutions

Signature Date

NOTES FOR COMPLETION OF THE PROXY FORM

1. For comprehensive notes for completion of the Proxy Form, please refer to the Notice of AGM. As explained in the Notice of AGM, shareholders are encouraged to appoint the Chair of the Meeting as their proxy for the 2026 AGM.

2. Shareholders are entitled to appoint another person to attend the meeting and vote on their behalf using the Proxy Form. The proxy need not be a shareholder. You may still attend the meeting and vote even if you return the Proxy Form. If you wish to appoint more than one proxy, please refer to the detailed instructions in the Notice of AGM.

3. If you do not indicate how you wish your proxy to vote, the proxy will be entitled to exercise discretion as to how and whether to vote on any resolution. In respect of any other business which may properly be conducted at the meeting including (without limitation) any motion to adjourn the meeting or to amend a resolution, your proxy may act at his or her discretion.

4. A vote 'withheld' is not a vote in law.

5. In order to be valid, this Proxy Form must be received by Equiniti by no later than 10.30 a.m. on Tuesday 2 June 2026.

6. Shareholders who wish to appoint a proxy electronically may do so at https://www.shareview.co.uk. You will need to create an online portfolio using your Shareholder Reference Number shown on the Proxy Form. Alternatively, if already registered with Equiniti's online portfolio service, Shareview, you can appoint your proxy electronically by logging on to your portfolio at https://www.shareview.co.uk using your usual ID and password. Once logged in, click 'View' on the 'My Investments' page, click on the link to vote then follow the on-screen instructions.

7. CREST members who wish to utilise the CREST proxy appointment service may do so by following the procedures described in the CREST manual and the Notice of AGM.

8. Additional paper Proxy Forms may be obtained from our Registrar, Equiniti. Alternatively, you may print or photocopy this Proxy Form the required number of times before completing it. Please do not use this Proxy Form to communicate a change of address or any other notifications. Please contact Equiniti separately and they will be able to assist you.